ENSMUSG00000025013


Mus musculus

Features
Gene ID: ENSMUSG00000025013
  
Biological name :Tll2
  
Synonyms : Q9WVM6 / Tll2 / Tolloid-like protein 2
  
Possible biological names infered from orthology : Q9Y6L7 / tolloid like 2
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 41083981
Gene end: 41206774
  
Corresponding Affymetrix probe sets: 10467538 (MoGene1.0st)   1421526_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025986
Ensembl peptide - ENSMUSP00000125973
NCBI entrez gene - 24087     See in Manteia.
MGI - MGI:1346044
RefSeq - XM_017318201
RefSeq - NM_011904
RefSeq - XM_006527092
RefSeq - XM_006527095
RefSeq Peptide - NP_036034
swissprot - E9Q5B9
swissprot - Q9WVM6
Ensembl - ENSMUSG00000025013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLL2ENSGALG00000005519Gallus gallus
 TLL2ENSG00000095587Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp1 / P98063 / Bone morphotic protein 1 / P13497* / bone morphogenetic protein 1*ENSMUSG0000002209872
Tll1 / tolloid-like / O43897* / tolloid like 1*ENSMUSG0000005362670
Cubn / Q9JLB4 / Cubilin / O60494*ENSMUSG0000002672629
Mfrp / Q8K480 / Membrane frizzled-related protein / Q9BY79*ENSMUSG0000003473913
Neto2 / Q8BNJ6 / Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), transcript variant 1, mRNA. / Q8NC67* / neuropilin and tolloid like 2*ENSMUSG0000003690212
Cdcp2 / Q8BQH6 / CUB domain-containing protein 2 / Q5VXM1*ENSMUSG0000004763612
Neto1 / Q8R4I7 / Neuropilin and tolloid-like protein 1 / Q8TDF5* / neuropilin and tolloid like 1*ENSMUSG0000005032111
Pcolce / Q61398 / Procollagen C-endopeptidase enhancer 1 / Q15113* / procollagen C-endopeptidase enhancer*ENSMUSG0000002971811
Q8R4W6 / Pcolce2 / Procollagen C-endopeptidase enhancer 2 / Q9UKZ9*ENSMUSG0000001535411


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001506  Peptidase M12A
 IPR001881  EGF-like calcium-binding domain
 IPR006026  Peptidase, metallopeptidase
 IPR013032  EGF-like, conserved site
 IPR015446  Bone morphogenetic protein 1/tolloid-like protein
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034036  Tolloid/BMP1 peptidase domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048632 negative regulation of skeletal muscle tissue growth IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Collagen biosynthesis and modifying enzymes
Anchoring fibril formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003397 increased muscle weight "greater than average muscle weight" [J:94134, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: B6N.129-Mstntm1Sjl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029718 Pcolce / Q61398 / Procollagen C-endopeptidase enhancer 1 / Q15113* / procollagen C-endopeptidase enhancer*  / complex
 ENSMUSG00000028763 Hspg2 / perlecan (heparan sulfate proteoglycan 2) / P98160* / heparan sulfate proteoglycan 2*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr