ENSMUSG00000034739


Mus musculus

Features
Gene ID: ENSMUSG00000034739
  
Biological name :Mfrp
  
Synonyms : Membrane frizzled-related protein / Mfrp / Q8K480
  
Possible biological names infered from orthology : Q9BY79
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.1
Gene start: 44101729
Gene end: 44109187
  
Corresponding Affymetrix probe sets: 10584653 (MoGene1.0st)   1424762_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124456
Ensembl peptide - ENSMUSP00000146138
Ensembl peptide - ENSMUSP00000145676
Ensembl peptide - ENSMUSP00000145633
Ensembl peptide - ENSMUSP00000125053
Ensembl peptide - ENSMUSP00000034654
NCBI entrez gene - 259172     See in Manteia.
MGI - MGI:2385957
RefSeq - NM_001190314
RefSeq - NM_147126
RefSeq Peptide - NP_001177243
RefSeq Peptide - NP_667337
swissprot - Q8K480
swissprot - A0A0U1RPV4
swissprot - A0A0U1RNR7
swissprot - A0A0U1RNN1
swissprot - E0CXS1
Ensembl - ENSMUSG00000034739
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:cabz01033205.3ENSDARG00000087814Danio rerio
 MFRPENSGALG00000032979Gallus gallus
 MFRPENSG00000235718Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cubn / Q9JLB4 / Cubilin / O60494*ENSMUSG0000002672627
Tll1 / tolloid-like / O43897* / tolloid like 1*ENSMUSG0000005362622
Tll2 / Q9WVM6 / Tolloid-like protein 2 / Q9Y6L7* / tolloid like 2*ENSMUSG0000002501322
Bmp1 / P98063 / Bone morphotic protein 1 / P13497* / bone morphogenetic protein 1*ENSMUSG0000002209821
Cdcp2 / Q8BQH6 / CUB domain-containing protein 2 / Q5VXM1*ENSMUSG0000004763618
Q8R4W6 / Pcolce2 / Procollagen C-endopeptidase enhancer 2 / Q9UKZ9*ENSMUSG0000001535416
Pcolce / Q61398 / Procollagen C-endopeptidase enhancer 1 / Q15113* / procollagen C-endopeptidase enhancer*ENSMUSG0000002971816
Neto1 / Q8R4I7 / Neuropilin and tolloid-like protein 1 / Q8TDF5* / neuropilin and tolloid like 1*ENSMUSG0000005032115
Neto2 / Q8BNJ6 / Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), transcript variant 1, mRNA. / Q8NC67* / neuropilin and tolloid like 2*ENSMUSG0000003690215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000859  CUB domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR020067  Frizzled domain
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR036055  LDL receptor-like superfamily
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mfrprdx/Mfrprdx,Per3tm1Drw/Per3tm1Drw
Genetic Background: involves: 129S4/SvJae

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Scnn1atm1Hum/Scnn1atm1Hum
Genetic Background: involves: 129/Sv

Allelic Composition: Mfrprdx/Mfrprdx,Per3tm1Drw/Per3tm1Drw
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mfrprdx/Mfrprdx
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mfrprdx/Mfrprdx
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfrprdx/Mfrprdx
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfrprdx/Mfrprdx
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mfrprdx/Mfrprdx
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mfrprd6/Mfrprd6
Genetic Background: involves: C3HfB6/Anl

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Mfrprdx/Mfrprdx,Per3tm1Drw/Per3tm1Drw
Genetic Background: involves: 129S4/SvJae

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scnn1atm1Hum/Scnn1atm1Hum
Genetic Background: involves: 129/Sv

Allelic Composition: Mfrprdx/Mfrprdx
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfrprdx/Mfrprdx
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfrprdx/Mfrprdx
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0012671 retinal spots "the appearance of roundish lesions on the retina, frequently white, and may be due to inflammation, degeneration, vasculitis, exudates, edema or mineral deposits" [MGI:csmith]
Show

Allelic Composition: Scnn1atm1Hum/Scnn1atm1Hum
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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