| MP:0000061 | fragile skeleton | "easily damaged or broken bones" [J:14208] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0000133 | abnormal long bone metaphysis morphology | "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
|
| MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0000272 | abnormal aorta morphology | "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Runx1tm2Dow/Runx1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae
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| MP:0000558 | abnormal tibia morphology | "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0000559 | abnormal femur morphology | "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
|
| MP:0000757 | herniated abdominal wall | "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae
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| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae
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| MP:0002397 | abnormal bone marrow morphology | "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0002896 | abnormal bone mineralization | "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
|
| MP:0003109 | short femur | "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0003408 | increased width of hypertrophic chondrocyte zone | "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0004214 | abnormal long bone diaphysis morphology | "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0004377 | small frontal bone | "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae
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| MP:0004384 | small interparietal bone | "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae
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| MP:0004418 | small parietal bone | "reduced size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae
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| MP:0004509 | abnormal pelvic girdle bone morphology | "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0004627 | abnormal trochanter morphology | "any structural anomaly of the bony prominences near the upper extremity of the femur; there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third); these normally serve as attachment points for hip and thigh muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0004675 | rib fractures | "a crack or break in the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0004984 | increased osteoclast cell number | "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0004987 | abnormal osteoblast cell number | "deviation from the average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0004991 | decreased bone strength | "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0004992 | increased bone resorption | "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0005029 | abnormal amnion | "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae
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| MP:0006065 | abnormal heart position | "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Runx1tm2Dow/Runx1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss
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| MP:0006397 | disorganized long bone epiphyseal plate | "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0006398 | increased long bone epiphyseal plate size | "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0008753 | abnormal osteocyte morphology | "any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0009283 | decreased gonadal fat pad weight | "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0009293 | decreased inguinal fat pad weight | |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0009445 | osteomalacia | "gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0010420 | muscular ventricular septal defect | "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com] |
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss
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| MP:0010869 | decreased bone trabecula number | "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0010872 | increased trabecular bone mass | "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0010924 | abnormal osteoid morphology | "any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0010965 | decreased compact bone volume | |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss
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| MP:0011643 | abnormal tendon collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0013624 | decreased femur compact bone thickness | "reduced width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0013626 | decreased femur yield load | "decrease in load (N) on the femur at which elastic deformation ends" [MGI:jwhite] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0013630 | increased bone trabecular spacing | "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0013633 | decreased femur maximal load | "decrease in the maximal load (N) sustained by the femur" [MGI:jwhite] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0013638 | decreased femur stiffness | "decrease in material stiffness (N/mm) during elastic deformation in the femur" [MGI:jwhite] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0013646 | decreased energy dissipated prior to femur fracture | "decrease in the fraction of total energy dissapated prior to ultimate material failure (high energy fracture) by the femur" [MGI:jwhite] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0013941 | abnormal enthesis morphology | "any structural anomaly of the connective tissue between tendon and bone insertion sites; the area which acts to transmit tensile load from soft tissues to bone; they may be of the dense fibrous connective tissue or fibrocartilage type; fibrous entheses attach directly to bone or periosteum primarily via fibrous tissue, and fibrocartilaginous entheses attach to bone through a transitional layer of fibrocartilage from the fibrous tendon tissue" [PMID:25489552] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0020010 | decreased bone mineral density of femur | "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0020039 | increased bone ossification | "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0030484 | abnormal osteocyte lacuna morphology | "any structural anomaly of the small cavity within the bone matrix that is occupied by an osteocyte cell body, and from which slender canaliculi radiate and penetrate the adjacent lamellae to anastomose with the canaliculi of neighboring lacunae, thus forming a system of cavities interconnected by minute canals" [https://medical-dictionary.thefreedictionary.com/osteocyte+lacuna] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0030487 | abnormal osteocyte dendritic process morphology | "any structural anomaly of the long, slender cytoplasmic processes by which mature osteocytes communicate with one another, receive mechanosensory signals and participate in the regulation of bone turnover; these processes radiate from the osteocyte cell body, run along narrow canaliculi, and are linked to other neighboring osteocytes processes by gap junctions, as well as to cytoplasmic processes of osteoblasts and bone lining cells on the bone surface" [https://www.hindawi.com/journals/bmri/2015/421746/, PMID:24419319] |
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Allelic Composition: Bmp1tm1.1Dgr/Bmp1tm1.1Dgr,Tll1tm2.1Dgr/Tll1tm2.1Dgr,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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