ENSDARG00000012076


Danio rerio

Features
Gene ID: ENSDARG00000012076
  
Biological name :apoa1a
  
Synonyms : apoa1a / apolipoprotein A-Ia / O42363
  
Possible biological names infered from orthology : APOA1 / apolipoprotein A1 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / P02647 / Q00623
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 37978501
Gene end: 37981521
  
Corresponding Affymetrix probe sets: Dr.1323.1.S1_at (Zebrafish Array)   NM_131128_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000025613
NCBI entrez gene - 30355     See in Manteia.
RefSeq - NM_131128
RefSeq Peptide - NP_571203
swissprot - O42363
ZFIN ID - ZDB-GENE-990415-14
Ensembl - ENSDARG00000012076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APOA1ENSGALG00000007114Gallus gallus
 APOA1ENSG00000118137Homo sapiens
 Apoa1ENSMUSG00000032083Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
apoa1b / apolipoprotein A-Ib / APOA1* / P02647* / apolipoprotein A1*ENSDARG0000010132437
apoa4b.2 / apolipoprotein A-IV b, tandem duplicate 2 / APOA4* / APOA5* / Q8C7G5* / P06727* / P06728* / Q6Q788* / apolipoprotein A5* / apolipoprotein A4* / Apolipoprotein A-IV * / Mus muscul...ENSDARG0000002086622
apoa4b.3 / apoa4b.2 / apolipoprotein A-IV b, tandem duplicate 3 / APOA4* / APOA5* / Q8C7G5* / P06727* / P06728* / Q6Q788* / apolipoprotein A5* / apolipoprotein A4* / Apolipoprotein A-IV * /...ENSDARG0000009492922
apoa4b.1 / apolipoprotein A-IV b, tandem duplicate 1 / APOA4* / APOA5* / Q8C7G5* / P06727* / P06728* / Q6Q788* / apolipoprotein A5* / apolipoprotein A4* / Apolipoprotein A-IV * / Mus muscul...ENSDARG0000004029821
apoa4a / apolipoprotein A-IV a / APOA4* / APOA5* / Q8C7G5* / P06727* / P06728* / Q6Q788* / apolipoprotein A5* / apolipoprotein A4* / Apolipoprotein A-IV * / Mus musculus apolipoprotein A-V ...ENSDARG0000010116016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000074  Apolipoprotein A/E


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IBA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010873 positive regulation of cholesterol esterification IBA
 biological_processGO:0010898 positive regulation of triglyceride catabolic process IBA
 biological_processGO:0019433 triglyceride catabolic process IBA
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IBA
 biological_processGO:0031102 neuron projection regeneration IBA
 biological_processGO:0033344 cholesterol efflux IBA
 biological_processGO:0033700 phospholipid efflux IBA
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IBA
 biological_processGO:0034380 high-density lipoprotein particle assembly IBA
 biological_processGO:0042157 lipoprotein metabolic process IBA
 biological_processGO:0042632 cholesterol homeostasis IBA
 biological_processGO:0043691 reverse cholesterol transport IBA
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process IBA
 biological_processGO:0046470 phosphatidylcholine metabolic process IBA
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IBA
 biological_processGO:0070328 triglyceride homeostasis IBA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0034364 high-density lipoprotein particle IBA
 cellular_componentGO:0042627 chylomicron IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0017127 cholesterol transporter activity IBA
 molecular_functionGO:0031210 phosphatidylcholine binding IBA
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ABC transporters in lipid homeostasis
Scavenging by Class B Receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Chylomicron assembly
HDL assembly
HDL clearance
HDL remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000101324 apoa1b / apolipoprotein A-Ib / APOA1* / P02647* / apolipoprotein A1*  / complex / reaction
 ENSDARG00000012076 apoa1a / O42363 / apolipoprotein A-Ia / APOA1* / Q00623* / P02647* / apolipoprotein A1* / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I*  / complex / reaction
 ENSDARG00000028071 bmp1a / bone morphogenetic protein 1a / BMP1* / P13497* / bone morphogenetic protein 1*  / reaction
 ENSDARG00000074635 abca1a / ATP-binding cassette, sub-family A (ABC1), member 1A / ABCA1* / P41233* / O95477* / ATP binding cassette subfamily A member 1* / ATP-binding cassette, sub-family A (ABC1), member 1*  / complex / reaction






 

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