ENSMUSG00000035722


Mus musculus

Features
Gene ID: ENSMUSG00000035722
  
Biological name :Abca7
  
Synonyms : Abca7 / ATP-binding cassette, sub-family A (ABC1), member 7 / Q91V24
  
Possible biological names infered from orthology : ATP binding cassette subfamily A member 7 / Q8IZY2
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79996494
Gene end: 80015572
  
Corresponding Affymetrix probe sets: 10364601 (MoGene1.0st)   1419238_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043090
Ensembl peptide - ENSMUSP00000115111
Ensembl peptide - ENSMUSP00000128121
NCBI entrez gene - 27403     See in Manteia.
MGI - MGI:1351646
RefSeq - XM_017313958
RefSeq - NM_001347081
RefSeq - NM_013850
RefSeq - XM_006513712
RefSeq - XM_006513713
RefSeq - XM_006513714
RefSeq - XM_017313957
RefSeq - XM_006513710
RefSeq - XM_006513711
RefSeq Peptide - NP_001334010
RefSeq Peptide - NP_038878
swissprot - Q91V24
swissprot - E9Q6G4
Ensembl - ENSMUSG00000035722
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:172302ENSDARG00000074221Danio rerio
 ABCA7ENSGALG00000002453Gallus gallus
 ABCA7ENSG00000064687Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abca1 / P41233 / ATP-binding cassette, sub-family A (ABC1), member 1 / O95477* / ATP binding cassette subfamily A member 1*ENSMUSG0000001524351
Abca4 / O35600 / ATP-binding cassette, sub-family A (ABC1), member 4 / P78363* / ATP binding cassette subfamily A member 4*ENSMUSG0000002812545
Abca2 / ATP-binding cassette, sub-family A (ABC1), member 2 / Q9BZC7* / ATP binding cassette subfamily A member 2*ENSMUSG0000002694437
Abca12 / ATP-binding cassette, sub-family A (ABC1), member 12 / Q86UK0* / ATP binding cassette subfamily A member 12*ENSMUSG0000005029632
Abca13 / Q5SSE9 / ATP-binding cassette, sub-family A (ABC1), member 13 / Q86UQ4* / ATP binding cassette subfamily A member 13*ENSMUSG0000000466831
Abca3 / Q8R420 / ATP-binding cassette, sub-family A (ABC1), member 3 / Q99758* / ATP binding cassette subfamily A member 3*ENSMUSG0000002413027
Abca16 / ATP-binding cassette, sub-family A (ABC1), member 16ENSMUSG0000005190024
Abca14 / ATP-binding cassette, sub-family A (ABC1), member 14ENSMUSG0000006201724
Abca15 / ATP-binding cassette, sub-family A (ABC1), member 15ENSMUSG0000005474624
Abca17 / E9PX95 / ATP-binding cassette, sub-family A (ABC1), member 17ENSMUSG0000003543524
Abca8a / Q8K442 / ATP-binding cassette, sub-family A (ABC1), member 8aENSMUSG0000004182820
Q8K440 / Abca8b / ATP-binding cassette, sub-family A (ABC1), member 8b / ABCA8* / O94911* / ATP binding cassette subfamily A member 8*ENSMUSG0000002062020
Abca5 / Q8K448 / ATP-binding cassette, sub-family A (ABC1), member 5 / Q8WWZ7* / ATP binding cassette subfamily A member 5*ENSMUSG0000001880020
Abca9 / Q8K449 / ATP-binding cassette, sub-family A (ABC1), member 9 / Q8IUA7* / ATP binding cassette subfamily A member 9*ENSMUSG0000004179720
Abca6 / Q8K441 / ATP-binding cassette, sub-family A (ABC1), member 6 / Q8N139* / ATP binding cassette subfamily A member 6*ENSMUSG0000004474918


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR017871  ABC transporter, conserved site
 IPR026082  ABC transporter A
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030369  ATP-binding cassette subfamily A member 7


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0010875 positive regulation of cholesterol efflux IDA
 biological_processGO:0018149 peptide cross-linking IDA
 biological_processGO:0033344 cholesterol efflux IEA
 biological_processGO:0033700 phospholipid efflux IEA
 biological_processGO:0034380 high-density lipoprotein particle assembly IEA
 biological_processGO:0034504 protein localization to nucleus IDA
 biological_processGO:0038027 apolipoprotein A-I-mediated signaling pathway IEA
 biological_processGO:0042985 negative regulation of amyloid precursor protein biosynthetic process IDA
 biological_processGO:0045332 phospholipid translocation IEA
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:1900223 positive regulation of amyloid-beta clearance IMP
 biological_processGO:1901076 positive regulation of engulfment of apoptotic cell IMP
 biological_processGO:1902430 negative regulation of amyloid-beta formation IMP
 biological_processGO:1902995 positive regulation of phospholipid efflux IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0001891 phagocytic cup IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005548 phospholipid transporter activity IDA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0034188 apolipoprotein A-I receptor activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0090554 phosphatidylcholine-translocating ATPase activity IEA
 molecular_functionGO:0090556 phosphatidylserine-translocating ATPase activity IEA


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0003928 increased heart rate variability "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission]
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Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0005385 cardiovascular system phenotype 
Show

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032083 Apoa1 / Q00623 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / P02647* / apolipoprotein A1*  / complex






 

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