ENSMUSG00000018800


Mus musculus

Features
Gene ID: ENSMUSG00000018800
  
Biological name :Abca5
  
Synonyms : Abca5 / ATP-binding cassette, sub-family A (ABC1), member 5 / Q8K448
  
Possible biological names infered from orthology : ATP binding cassette subfamily A member 5 / Q8WWZ7
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 110269369
Gene end: 110337716
  
Corresponding Affymetrix probe sets: 10392642 (MoGene1.0st)   1434474_at (Mouse Genome 430 2.0 Array)   1459391_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047927
Ensembl peptide - ENSMUSP00000120708
Ensembl peptide - ENSMUSP00000118328
NCBI entrez gene - 217265     See in Manteia.
MGI - MGI:2386607
RefSeq - NM_147219
RefSeq - XM_006533065
RefSeq Peptide - NP_671752
swissprot - A2AEP6
swissprot - Q8K448
swissprot - A2AEP5
Ensembl - ENSMUSG00000018800
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abca5ENSDARG00000074041Danio rerio
 ABCA5ENSGALG00000004333Gallus gallus
 ABCA5ENSG00000154265Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K440 / Abca8b / ATP-binding cassette, sub-family A (ABC1), member 8b / ABCA8* / O94911* / ATP binding cassette subfamily A member 8*ENSMUSG0000002062041
Abca9 / Q8K449 / ATP-binding cassette, sub-family A (ABC1), member 9 / Q8IUA7* / ATP binding cassette subfamily A member 9*ENSMUSG0000004179741
Abca6 / Q8K441 / ATP-binding cassette, sub-family A (ABC1), member 6 / Q8N139* / ATP binding cassette subfamily A member 6*ENSMUSG0000004474939
Abca8a / Q8K442 / ATP-binding cassette, sub-family A (ABC1), member 8aENSMUSG0000004182839
Abca7 / Q91V24 / ATP-binding cassette, sub-family A (ABC1), member 7 / Q8IZY2* / ATP binding cassette subfamily A member 7*ENSMUSG0000003572226
Abca1 / P41233 / ATP-binding cassette, sub-family A (ABC1), member 1 / O95477* / ATP binding cassette subfamily A member 1*ENSMUSG0000001524326
Abca4 / O35600 / ATP-binding cassette, sub-family A (ABC1), member 4 / P78363* / ATP binding cassette subfamily A member 4*ENSMUSG0000002812526
Abca15 / ATP-binding cassette, sub-family A (ABC1), member 15ENSMUSG0000005474625
Abca2 / ATP-binding cassette, sub-family A (ABC1), member 2 / Q9BZC7* / ATP binding cassette subfamily A member 2*ENSMUSG0000002694425
Abca3 / Q8R420 / ATP-binding cassette, sub-family A (ABC1), member 3 / Q99758* / ATP binding cassette subfamily A member 3*ENSMUSG0000002413025
Abca14 / ATP-binding cassette, sub-family A (ABC1), member 14ENSMUSG0000006201724
Abca16 / ATP-binding cassette, sub-family A (ABC1), member 16ENSMUSG0000005190024
Abca13 / Q5SSE9 / ATP-binding cassette, sub-family A (ABC1), member 13 / Q86UQ4* / ATP binding cassette subfamily A member 13*ENSMUSG0000000466824
Abca17 / E9PX95 / ATP-binding cassette, sub-family A (ABC1), member 17ENSMUSG0000003543523
Abca12 / ATP-binding cassette, sub-family A (ABC1), member 12 / Q86UK0* / ATP binding cassette subfamily A member 12*ENSMUSG0000005029623


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR017871  ABC transporter, conserved site
 IPR026082  ABC transporter A
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030367  ATP-binding cassette subfamily A member 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IMP
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0033344 cholesterol efflux IMP
 biological_processGO:0034375 high-density lipoprotein particle remodeling IMP
 biological_processGO:0043691 reverse cholesterol transport IC
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0003503 decreased activity of thyroid 
Show

Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0005314 absent thyroid gland " missing endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]
Show

Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
Show

Allelic Composition: ApcMin/Apc+,Blmtm1Grdn/Blm+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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