ENSMUSG00000026944


Mus musculus

Features
Gene ID: ENSMUSG00000026944
  
Biological name :Abca2
  
Synonyms : Abca2 / ATP-binding cassette, sub-family A (ABC1), member 2
  
Possible biological names infered from orthology : ATP binding cassette subfamily A member 2 / Q9BZC7
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 25428703
Gene end: 25448540
  
Corresponding Affymetrix probe sets: 10470050 (MoGene1.0st)   1449302_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099983
NCBI entrez gene - 11305     See in Manteia.
MGI - MGI:99606
RefSeq - XM_006497616
RefSeq - NM_007379
RefSeq - XM_006497614
RefSeq - XM_006497615
RefSeq - XM_006497609
RefSeq - XM_006497610
RefSeq - XM_006497611
RefSeq - XM_006497612
RefSeq Peptide - NP_031405
swissprot - A2AJ26
Ensembl - ENSMUSG00000026944
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abca2ENSDARG00000013500Danio rerio
 ABCA2ENSGALG00000036894Gallus gallus
 ABCA2ENSG00000107331Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abca1 / P41233 / ATP-binding cassette, sub-family A (ABC1), member 1 / O95477* / ATP binding cassette subfamily A member 1*ENSMUSG0000001524339
Abca4 / O35600 / ATP-binding cassette, sub-family A (ABC1), member 4 / P78363* / ATP binding cassette subfamily A member 4*ENSMUSG0000002812536
Abca7 / Q91V24 / ATP-binding cassette, sub-family A (ABC1), member 7 / Q8IZY2* / ATP binding cassette subfamily A member 7*ENSMUSG0000003572233
Abca13 / Q5SSE9 / ATP-binding cassette, sub-family A (ABC1), member 13 / Q86UQ4* / ATP binding cassette subfamily A member 13*ENSMUSG0000000466828
Abca12 / ATP-binding cassette, sub-family A (ABC1), member 12 / Q86UK0* / ATP binding cassette subfamily A member 12*ENSMUSG0000005029628
Abca3 / Q8R420 / ATP-binding cassette, sub-family A (ABC1), member 3 / Q99758* / ATP binding cassette subfamily A member 3*ENSMUSG0000002413025
Abca17 / E9PX95 / ATP-binding cassette, sub-family A (ABC1), member 17ENSMUSG0000003543523
Abca14 / ATP-binding cassette, sub-family A (ABC1), member 14ENSMUSG0000006201722
Abca15 / ATP-binding cassette, sub-family A (ABC1), member 15ENSMUSG0000005474622
Abca16 / ATP-binding cassette, sub-family A (ABC1), member 16ENSMUSG0000005190021
Abca9 / Q8K449 / ATP-binding cassette, sub-family A (ABC1), member 9 / Q8IUA7* / ATP binding cassette subfamily A member 9*ENSMUSG0000004179718
Abca8a / Q8K442 / ATP-binding cassette, sub-family A (ABC1), member 8aENSMUSG0000004182817
Q8K440 / Abca8b / ATP-binding cassette, sub-family A (ABC1), member 8b / ABCA8* / O94911* / ATP binding cassette subfamily A member 8*ENSMUSG0000002062017
Abca5 / Q8K448 / ATP-binding cassette, sub-family A (ABC1), member 5 / Q8WWZ7* / ATP binding cassette subfamily A member 5*ENSMUSG0000001880017
Abca6 / Q8K441 / ATP-binding cassette, sub-family A (ABC1), member 6 / Q8N139* / ATP binding cassette subfamily A member 6*ENSMUSG0000004474916


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR017871  ABC transporter, conserved site
 IPR026082  ABC transporter A
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0032383 regulation of intracellular cholesterol transport IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070723 response to cholesterol IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0003459 increased fear-related response "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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