ENSMUSG00000015243


Mus musculus

Features
Gene ID: ENSMUSG00000015243
  
Biological name :Abca1
  
Synonyms : Abca1 / ATP-binding cassette, sub-family A (ABC1), member 1 / P41233
  
Possible biological names infered from orthology : ATP binding cassette subfamily A member 1 / O95477
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B2
Gene start: 53030787
Gene end: 53159895
  
Corresponding Affymetrix probe sets: 10512949 (MoGene1.0st)   1421839_at (Mouse Genome 430 2.0 Array)   1421840_at (Mouse Genome 430 2.0 Array)   1450392_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030010
NCBI entrez gene - 11303     See in Manteia.
MGI - MGI:99607
RefSeq - XM_006537556
RefSeq - NM_013454
RefSeq - XM_006537554
RefSeq - XM_006537555
RefSeq Peptide - NP_038482
swissprot - P41233
Ensembl - ENSMUSG00000015243
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abca1aENSDARG00000074635Danio rerio
 ABCA1ENSGALG00000015433Gallus gallus
 ABCA1ENSG00000165029Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abca4 / O35600 / ATP-binding cassette, sub-family A (ABC1), member 4 / P78363* / ATP binding cassette subfamily A member 4*ENSMUSG0000002812550
Abca7 / Q91V24 / ATP-binding cassette, sub-family A (ABC1), member 7 / Q8IZY2* / ATP binding cassette subfamily A member 7*ENSMUSG0000003572249
Abca2 / ATP-binding cassette, sub-family A (ABC1), member 2 / Q9BZC7* / ATP binding cassette subfamily A member 2*ENSMUSG0000002694442
Abca12 / ATP-binding cassette, sub-family A (ABC1), member 12 / Q86UK0* / ATP binding cassette subfamily A member 12*ENSMUSG0000005029633
Abca13 / Q5SSE9 / ATP-binding cassette, sub-family A (ABC1), member 13 / Q86UQ4* / ATP binding cassette subfamily A member 13*ENSMUSG0000000466831
Abca3 / Q8R420 / ATP-binding cassette, sub-family A (ABC1), member 3 / Q99758* / ATP binding cassette subfamily A member 3*ENSMUSG0000002413027
Abca17 / E9PX95 / ATP-binding cassette, sub-family A (ABC1), member 17ENSMUSG0000003543525
Abca14 / ATP-binding cassette, sub-family A (ABC1), member 14ENSMUSG0000006201725
Abca15 / ATP-binding cassette, sub-family A (ABC1), member 15ENSMUSG0000005474625
Abca16 / ATP-binding cassette, sub-family A (ABC1), member 16ENSMUSG0000005190024
Abca5 / Q8K448 / ATP-binding cassette, sub-family A (ABC1), member 5 / Q8WWZ7* / ATP binding cassette subfamily A member 5*ENSMUSG0000001880019
Abca9 / Q8K449 / ATP-binding cassette, sub-family A (ABC1), member 9 / Q8IUA7* / ATP binding cassette subfamily A member 9*ENSMUSG0000004179719
Abca8a / Q8K442 / ATP-binding cassette, sub-family A (ABC1), member 8aENSMUSG0000004182819
Q8K440 / Abca8b / ATP-binding cassette, sub-family A (ABC1), member 8b / ABCA8* / O94911* / ATP binding cassette subfamily A member 8*ENSMUSG0000002062019
Abca6 / Q8K441 / ATP-binding cassette, sub-family A (ABC1), member 6 / Q8N139* / ATP binding cassette subfamily A member 6*ENSMUSG0000004474918


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR017871  ABC transporter, conserved site
 IPR026082  ABC transporter A
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002790 peptide secretion IMP
 biological_processGO:0006497 protein lipidation IMP
 biological_processGO:0006911 phagocytosis, engulfment IMP
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010875 positive regulation of cholesterol efflux IMP
 biological_processGO:0015914 phospholipid transport IEA
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0032367 intracellular cholesterol transport IEA
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction IEA
 biological_processGO:0033344 cholesterol efflux IEA
 biological_processGO:0033700 phospholipid efflux IEA
 biological_processGO:0034380 high-density lipoprotein particle assembly IEA
 biological_processGO:0034616 response to laminar fluid shear stress IEA
 biological_processGO:0038027 apolipoprotein A-I-mediated signaling pathway IEA
 biological_processGO:0042157 lipoprotein metabolic process IMP
 biological_processGO:0042158 lipoprotein biosynthetic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043691 reverse cholesterol transport IMP
 biological_processGO:0045332 phospholipid translocation IEA
 biological_processGO:0050702 interleukin-1 beta secretion IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055091 phospholipid homeostasis IEA
 biological_processGO:0060155 platelet dense granule organization IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071300 cellular response to retinoic acid IDA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0005548 phospholipid transporter activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IDA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0017127 cholesterol transporter activity IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0031267 small GTPase binding IEA
 molecular_functionGO:0034185 apolipoprotein binding IEA
 molecular_functionGO:0034186 apolipoprotein A-I binding IEA
 molecular_functionGO:0034188 apolipoprotein A-I receptor activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0090554 phosphatidylcholine-translocating ATPase activity IEA
 molecular_functionGO:0090556 phosphatidylserine-translocating ATPase activity IEA


Pathways (from Reactome)
Pathway description
HDL assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Artm4(AR)Dmr/Y
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

Allelic Composition: Abca1tm1Jp/Abca1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Abca1tm2Jp/Abca1tm2Jp,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Abca1m4620Dajl/Abca1m4620Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

Allelic Composition: Abca1m4620Dajl/Abca1+
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Abca1tm1Jp/Abca1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * SJL

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: B6.129S4-Ndufs4tm1.1Rpa

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: B6.129S4-Ndufs4tm1.1Rpa

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen,Tg(APOA1)1Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

Allelic Composition: Abca1m4620Dajl/Abca1m4620Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Abca1tm1b(EUCOMM)Hmgu/Abca1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Artm4(AR)Dmr/Y
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: B6.129S4-Ndufs4tm1.1Rpa

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002646 increased cholesterol absorption "augmented ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic Background: involves: 129 * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

 MP:0003192 increased cholesterol efflux "greater level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

 MP:0003193 decreased cholesterol efflux "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0003981 decreased circulating phospholipid level "reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm2Jp/Abca1tm2Jp,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004254 cerebral amyloid angiopathy "a pathological condition where there is a deposition of amyloid in the walls of the small cerebral vessels which supply the brain; this results in an increased risk of infarcts and/or intracerebral hemorrhage, possibly resulting in dementia" [acv:Alicia Valenzuela_Genetic Resources Curator]
Show

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

Allelic Composition: Abca1tm1Jp/Abca1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Abca1m4620Dajl/Abca1m4620Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

Allelic Composition: Abca1m4620Dajl/Abca1+
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Abca1tm1Jp/Abca1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Abca1mpc227H/Abca1mpc227H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

Allelic Composition: Abca1tm1Jp/Abca1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Wpfl/Abca1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005401 abnormal fat-soluble vitamin level "anomalous concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function and which require the presence of lipids for assimilation in the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca1tm2Jp/Abca1tm2Jp,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0006084 abnormal circulating phospholipid level "anomalous concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Abca1tm1Jdm/Abca1+
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

Allelic Composition: Abca1tm1Jp/Abca1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0008690 increased interleukin-23 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
Show

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009080 uterus inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0010075 abnormal circulating plant sterol concentration "anomaly in the amount per unit of phytosterols in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0010161 decreased brain cholesterol level "less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: DBA/1LacJ-Abca1tm1Jdm

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Abca1tm1b(EUCOMM)Hmgu/Abca1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / reaction
 ENSMUSG00000032083 Apoa1 / Q00623 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / P02647* / apolipoprotein A1*  / reaction / complex
 ENSMUSG00000015243 Abca1 / P41233 / ATP-binding cassette, sub-family A (ABC1), member 1 / O95477* / ATP binding cassette subfamily A member 1*  / complex
 ENSMUSG00000060166 Q5Y5T5 / Zdhhc8 / zinc finger, DHHC domain containing 8 / Q9ULC8* / zinc finger DHHC-type containing 8*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr