Manteia - Molecule gene

ENSMUSG00000021278

Mus musculus

Features

Gene ID:	ENSMUSG00000021278

Biological name :	Amn

Synonyms :	Amn / Protein amnionless / Q99JB7

Possible biological names infered from orthology :	amnion associated transmembrane protein / Q9BXJ7

Species:	Mus musculus

Chr. number:	12
Strand:	1
Band:	F1
Gene start:	111271095
Gene end:	111276426

Corresponding Affymetrix probe sets:	10398635 (MoGene1.0st) 1417920_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000021707 NCBI entrez gene - 93835 See in Manteia. MGI - MGI:1934943 RefSeq - NM_033603 RefSeq Peptide - NP_291081 swissprot - Q99JB7 Ensembl - ENSMUSG00000021278

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
amn	ENSDARG00000062947	Danio rerio
AMN	ENSGALG00000011391	Gallus gallus
AMN	ENSG00000166126	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR026112	Amnionless

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006898	receptor-mediated endocytosis	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007588	excretion	IMP
biological_process	GO:0008104	protein localization	IMP
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0015889	cobalamin transport	IEA
biological_process	GO:0043001	Golgi to plasma membrane protein transport	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005905	clathrin-coated pit	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0016324	apical plasma membrane	IEA
cellular_component	GO:0030139	endocytic vesicle	IEA
cellular_component	GO:0031526	brush border membrane	IEA
cellular_component	GO:0045177	apical part of cell	IDA
molecular_function	GO:0005102	signaling receptor binding	IEA

Pathways (from Reactome)

Pathway description

Cobalamin (Cbl, vitamin B12) transport and metabolism

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Aars^sti/Aars^tm1.1Slac Genetic Background: involves: C57BL/6J * FVB/N
MP:0000484	abnormal pulmonary artery morphology	"structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]	Show Allelic Composition: Aars^sti/Aars^tm1.1Slac Genetic Background: involves: C57BL/6J * FVB/N
MP:0000932	absent notochord	"missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Aars^sti/Aars^tm1.1Slac Genetic Background: involves: C57BL/6J * FVB/N
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Aars^sti/Aars^tm1.1Slac Genetic Background: involves: C57BL/6J * FVB/N
MP:0001675	abnormal ectoderm development	"failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Amn^amn/Amn^amn Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0001680	abnormal mesoderm development	"failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001683	absent mesoderm	"missing or failure to differentiate the middle primary germ layer " [J:40594]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Amn^amn/Amn^amn Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Amn^amn/Amn^amn Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Amn^tm1Ehl/Amn^tm1Ehl Genetic Background: involves: 129X1/SvJ
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002230	abnormal primitive streak formation	"anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Amn^amn/Amn^amn Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0002231	abnormal primitive streak morphology	"anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J
MP:0003861	abnormal nervous system development	"impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004073	caudal body truncation	"caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Amn^amn/Amn^amn Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Aars^sti/Aars^tm1.1Slac Genetic Background: involves: C57BL/6J * FVB/N
MP:0005030	absent amnion	"missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J
MP:0006386	absent somites	"missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Amn^amn/Amn^amn Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0009331	absent primitive node	"absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Amn^amn/Amn^amn Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0010466	vascular ring	"the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]	Show Allelic Composition: Aars^sti/Aars^tm1.1Slac Genetic Background: involves: C57BL/6J * FVB/N
MP:0010488	abnormal left subclavian artery morphology	"any structural anomaly of the artery that extends from the aortic arch to the left side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aars^sti/Aars^tm1.1Slac Genetic Background: involves: C57BL/6J * FVB/N
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Amn^amn/Amn^amn Genetic Background: involves: 129S1/SvImJ * C57BL/6J Allelic Composition: Amn^tm1Ehl/Amn^tm1Ehl Genetic Background: involves: 129X1/SvJ
MP:0011666	double outlet right ventricle, ventricular defect committed to aorta	"a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present" [MGI:csmith]	Show Allelic Composition: Aars^sti/Aars^tm1.1Slac Genetic Background: involves: C57BL/6J * FVB/N
MP:0013504	increased embryonic tissue cell apoptosis	"increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Cacna1a^tg/Cacna1a^tg Genetic Background: involves: C57BL/6J * DBA/2J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024682	Gif / P52787 / Gastric intrinsic factor / P27352*	/ reaction / complex
ENSMUSG00000026726	Cubn / Q9JLB4 / Cubilin / O60494*	/ complex
ENSMUSG00000032083	Apoa1 / Q00623 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / P02647* / apolipoprotein A1*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr