ENSMUSG00000024682


Mus musculus

Features
Gene ID: ENSMUSG00000024682
  
Biological name :Gif
  
Synonyms : Gastric intrinsic factor / Gif / P52787
  
Possible biological names infered from orthology : P27352
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 11747554
Gene end: 11763447
  
Corresponding Affymetrix probe sets: 10461652 (MoGene1.0st)   1419020_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025585
NCBI entrez gene - 14603     See in Manteia.
MGI - MGI:1202394
RefSeq - NM_008118
RefSeq - XM_006526688
RefSeq Peptide - NP_032144
swissprot - P52787
Ensembl - ENSMUSG00000024682
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GIFENSG00000134812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcn2 / O88968 / Transcobalamin-2 / P20062*ENSMUSG0000002043226


Protein motifs (from Interpro)
Interpro ID Name
 IPR002157  Cobalamin (vitamin B12)-binding protein
 IPR027954  Domain of unknown function DUF4430


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006824 cobalt ion transport IEA
 biological_processGO:0015889 cobalamin transport ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0031419 cobalamin binding ISO


Pathways (from Reactome)
Pathway description
Cobalamin (Cbl, vitamin B12) transport and metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0010330 abnormal circulating lipoprotein level "any anomaly in the concentration in the blood of any complex or compound containing both lipid and protein, are important components of biological membranes and myelin, and participate in lipid transport" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0011227 abnormal vitamin B12 level "any anomaly in the concentration of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom" [GO:0009236]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021278 Amn / Q99JB7 / Protein amnionless / Q9BXJ7* / amnion associated transmembrane protein*  / reaction / complex
 ENSMUSG00000026726 Cubn / Q9JLB4 / Cubilin / O60494*  / reaction / complex






 

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