ENSMUSG00000054932


Mus musculus

Features
Gene ID: ENSMUSG00000054932
  
Biological name :Afp
  
Synonyms : Afp / Alpha-fetoprotein / P02772
  
Possible biological names infered from orthology : P02771
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 90490737
Gene end: 90508907
  
Corresponding Affymetrix probe sets: 10523078 (MoGene1.0st)   1416645_a_at (Mouse Genome 430 2.0 Array)   1416646_at (Mouse Genome 430 2.0 Array)   1436879_x_at (Mouse Genome 430 2.0 Array)   1436880_at (Mouse Genome 430 2.0 Array)   1436881_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144019
Ensembl peptide - ENSMUSP00000041006
NCBI entrez gene - 11576     See in Manteia.
MGI - MGI:87951
RefSeq - NM_007423
RefSeq Peptide - NP_031449
swissprot - A0A0J9YU60
swissprot - P02772
Ensembl - ENSMUSG00000054932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000011658Gallus gallus
 AFPENSG00000081051Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
5830473C10Rik / RIKEN cDNA 5830473C10 geneENSMUSG0000007069038
Alb / P07724 / Serum albumin / P02768* / albumin*ENSMUSG0000002936834
Afm / O89020 / Afamin / P43652*ENSMUSG0000002936933
Gc / P21614 / Vitamin D-binding protein / P02774* / GC, vitamin D binding protein*ENSMUSG0000003554016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000264  ALB/AFP/VDB
 IPR014760  Serum albumin, N-terminal
 IPR020857  Serum albumin, conserved site
 IPR020858  Serum albumin-like
 IPR021177  Serum albumin/Alpha-fetoprotein/Afamin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001542 ovulation from ovarian follicle IMP
 biological_processGO:0019953 sexual reproduction IMP
 biological_processGO:0042448 progesterone metabolic process IMP
 biological_processGO:0060395 SMAD protein signal transduction IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53Bbl/Trp53+
Genetic Background: C57BL/6JSfdAnu-Trp53Bbl/Anu

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Afptm1Ibmm/Afptm1Ibmm
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53Bbl/Trp53+
Genetic Background: C57BL/6JSfdAnu-Trp53Bbl/Anu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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