ENSMUSG00000030236


Mus musculus

Features
Gene ID: ENSMUSG00000030236
  
Biological name :Slco1b2
  
Synonyms : Q9JJL3 / Slco1b2 / Solute carrier organic anion transporter family member 1B2
  
Possible biological names infered from orthology : AC011604.2 / G3V0H7 / Q9NPD5 / Q9Y6L6 / SLCO1B1 / SLCO1B3 / SLCO1B7 / solute carrier organic anion transporter family member 1B1 / solute carrier organic anion transporter family member 1B3 / solute carrier organic anion transporter family member 1B7 (putative)
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G2
Gene start: 141629518
Gene end: 141686646
  
Corresponding Affymetrix probe sets: 10542615 (MoGene1.0st)   1427826_a_at (Mouse Genome 430 2.0 Array)   1449394_at (Mouse Genome 430 2.0 Array)   1452494_s_at (Mouse Genome 430 2.0 Array)   1452569_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044326
Ensembl peptide - ENSMUSP00000144747
NCBI entrez gene - 28253     See in Manteia.
MGI - MGI:1351899
RefSeq - XM_017321611
RefSeq - NM_020495
RefSeq - XM_006506963
RefSeq Peptide - NP_065241
swissprot - Q9JJL3
swissprot - A0A0N4SUN2
Ensembl - ENSMUSG00000030236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLCO1B3ENSGALG00000019277Gallus gallus
 AC011604.2ENSG00000257046Homo sapiens
 G3V0H7ENSG00000205754Homo sapiens
 Q9NPD5ENSG00000111700Homo sapiens
 Q9Y6L6ENSG00000134538Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ERB5 / Slco1c1 / solute carrier organic anion transporter family, member 1c1 / Q9NYB5*ENSMUSG0000003023541
Q9EP96 / Slco1a4 / Mus musculus solute carrier organic anion transporter family, member 1a4 (Slco1a4), transcript variant 2, mRNA. / P46721* / SLCO1A2* / solute carrier organic anion transp...ENSMUSG0000003023738
Q9QXZ6 / Slco1a1 / solute carrier organic anion transporter family, member 1a1 / P46721* / SLCO1A2* / solute carrier organic anion transporter family member 1A2*ENSMUSG0000004169838
Slco1a5 / solute carrier organic anion transporter family, member 1a5 / P46721* / SLCO1A2* / solute carrier organic anion transporter family member 1A2*ENSMUSG0000006397538
Q99J94 / Slco1a6 / Solute carrier organic anion transporter family member 1A6 / P46721* / SLCO1A2* / solute carrier organic anion transporter family member 1A2*ENSMUSG0000007926236
Gm5724 / P46721* / SLCO1A2* / solute carrier organic anion transporter family member 1A2*ENSMUSG0000008492734
Q8R3L5 / Slco3a1 / Solute carrier organic anion transporter family member 3A1 / Q9UIG8*ENSMUSG0000002579031
Slco5a1 / solute carrier organic anion transporter family, member 5A1 / Q9H2Y9*ENSMUSG0000002593829
Q9EPT5 / Slco2a1 / solute carrier organic anion transporter family, member 2a1 / Q92959*ENSMUSG0000003254828
Q8BXB6 / Slco2b1 / solute carrier organic anion transporter family, member 2b1 / O94956*ENSMUSG0000003073728
Q8K078 / Slco4a1 / Mus musculus solute carrier organic anion transporter family, member 4a1 (Slco4a1), transcript variant 2, mRNA. / Q96BD0* / solute carrier organic anion transporter famil...ENSMUSG0000003896326
Q8BGD4 / Slco4c1 / Solute carrier organic anion transporter family member 4C1 / Q6ZQN7*ENSMUSG0000004069325
Slco6c1 / solute carrier organic anion transporter family, member 6c1 / Q86UG4* / SLCO6A1* / solute carrier organic anion transporter family member 6A1*ENSMUSG0000002633119


Protein motifs (from Interpro)
Interpro ID Name
 IPR002350  Kazal domain
 IPR004156  Organic anion transporter polypeptide
 IPR020846  Major facilitator superfamily domain
 IPR036058  Kazal domain superfamily
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0006857 oligopeptide transport IEA
 biological_processGO:0015721 bile acid and bile salt transport IEA
 biological_processGO:0015893 drug transport IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035672 oligopeptide transmembrane transport IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043252 sodium-independent organic anion transport IBA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008514 organic anion transmembrane transporter activity ISS
 molecular_functionGO:0015125 bile acid transmembrane transporter activity IEA
 molecular_functionGO:0015238 drug transmembrane transporter activity IEA
 molecular_functionGO:0015347 sodium-independent organic anion transmembrane transporter activity IBA
 molecular_functionGO:0035673 oligopeptide transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Transport of organic anions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000199 abnormal circulating albumin level "aberrant concentration in the blood of this most abundant of the plasma proteins " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0006357 abnormal circulating mineral level "anomalous concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic Background: B6.129S1-Slco1b2tm1Cdk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029368 Alb / P07724 / Serum albumin / P02768* / albumin*  / reaction






 

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