ENSG00000110169


Homo sapiens

Features
Gene ID: ENSG00000110169
  
Biological name :HPX
  
Synonyms : hemopexin / HPX / P02790
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 6431049
Gene end: 6442617
  
Corresponding Affymetrix probe sets: 210013_at (Human Genome U133 Plus 2.0 Array)   39763_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265983
Ensembl peptide - ENSP00000479146
NCBI entrez gene - 3263     See in Manteia.
OMIM - 142290
RefSeq - NM_000613
RefSeq Peptide - NP_000604
swissprot - P02790
swissprot - Q9BS19
Ensembl - ENSG00000110169
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpxENSDARG00000012609Danio rerio
 zgc:152945ENSDARG00000051912Danio rerio
 HPXENSGALG00000022586Gallus gallus
 HpxENSMUSG00000030895Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR016358  Hemopexin
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002639 positive regulation of immunoglobulin production IEA
 biological_processGO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0015886 heme transport TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0020027 hemoglobin metabolic process IEA
 biological_processGO:0042168 heme metabolic process IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0051246 regulation of protein metabolic process IEA
 biological_processGO:0060332 positive regulation of response to interferon-gamma IEA
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071682 endocytic vesicle lumen TAS
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015232 heme transporter activity TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188536 HBA2 / P69905 / hemoglobin subunit alpha 2  / reaction
 ENSG00000123384 LRP1 / Q07954 / LDL receptor related protein 1  / complex / reaction
 ENSG00000163631 ALB / P02768 / albumin  / reaction
 ENSG00000110169 HPX / P02790 / hemopexin  / reaction
 ENSG00000244734 HBB / P68871 / hemoglobin subunit beta  / reaction






 

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