ENSMUSG00000027978


Mus musculus

Features
Gene ID: ENSMUSG00000027978
  
Biological name :Prss12
  
Synonyms : O08762 / protease, serine 12 neurotrypsin (motopsin) / Prss12
  
Possible biological names infered from orthology : P56730 / serine protease 12
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 123446913
Gene end: 123506597
  
Corresponding Affymetrix probe sets: 10495854 (MoGene1.0st)   1420388_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029603
NCBI entrez gene - 19142     See in Manteia.
MGI - MGI:1100881
RefSeq - NM_008939
RefSeq Peptide - NP_032965
swissprot - O08762
Ensembl - ENSMUSG00000027978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prss12ENSDARG00000061830Danio rerio
 PRSS12ENSGALG00000012004Gallus gallus
 P56730ENSG00000164099Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dmbt1 / Mus musculus deleted in malignant brain tumors 1 (Dmbt1), transcript variant 1, mRNA. / Q9UGM3* / deleted in malignant brain tumors 1*ENSMUSG0000004751726
Ssc5d / Q8BV57 / Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D / A1L4H1* / scavenger receptor cysteine rich family member with 5 domains*ENSMUSG0000003527924
Cd163l1 / CD163 molecule-like 1 / Q4G0T1* / SCART1* / scavenger receptor family member expressed on T cells 1*ENSMUSG0000002546123
Cd163 / Q2VLH6 / Scavenger receptor cysteine-rich type 1 protein M130 Soluble CD163 / Q86VB7* / CD163 molecule*ENSMUSG0000000884522
5830411N06Rik / RIKEN cDNA 5830411N06 gene / Q4G0T1* / SCART1* / scavenger receptor family member expressed on T cells 1*ENSMUSG0000005467222
Ssc4d / A1L0T3 / scavenger receptor cysteine rich family, 4 domains / Q8WTU2* / scavenger receptor cysteine rich family member with 4 domains*ENSMUSG0000002969917
Cd5l / Q9QWK4 / CD5 antigen-like / O43866* / CD5 molecule like*ENSMUSG0000001585413
Q8BZE1 / 5430419D17Rik / Putative DMBT1-like protein ENSMUSG0000000620410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR001190  SRCR domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR013806  Kringle-like fold
 IPR017448  SRCR-like domain
 IPR018056  Kringle, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IMP
 biological_processGO:0006887 exocytosis IDA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0031638 zymogen activation IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0043083 synaptic cleft IDA
 cellular_componentGO:0043195 terminal bouton IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0008233 peptidase activity IMP
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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