ENSG00000177575


Homo sapiens

Features
Gene ID: ENSG00000177575
  
Biological name :CD163
  
Synonyms : CD163 / CD163 molecule / Q86VB7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.31
Gene start: 7470813
Gene end: 7503893
  
Corresponding Affymetrix probe sets: 203645_s_at (Human Genome U133 Plus 2.0 Array)   215049_x_at (Human Genome U133 Plus 2.0 Array)   216233_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444071
Ensembl peptide - ENSP00000439226
Ensembl peptide - ENSP00000445438
Ensembl peptide - ENSP00000352071
Ensembl peptide - ENSP00000379863
Ensembl peptide - ENSP00000403885
NCBI entrez gene - 9332     See in Manteia.
OMIM - 605545
RefSeq - XM_017020231
RefSeq - NM_004244
RefSeq - NM_203416
RefSeq - XM_005253528
RefSeq - XM_005253529
RefSeq Peptide - NP_004235
RefSeq Peptide - NP_981961
swissprot - H0YFM0
swissprot - H0YGZ7
swissprot - Q86VB7
swissprot - F5GZZ9
swissprot - C9JHR8
Ensembl - ENSG00000177575
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX784029.3ENSDARG00000096156Danio rerio
 BX784029.4ENSDARG00000096184Danio rerio
 si:ch211-161n3.3ENSDARG00000092989Danio rerio
 si:ch211-161n3.4ENSDARG00000045752Danio rerio
 si:ch211-161n3.5ENSDARG00000095981Danio rerio
 si:dkey-21h14.10ENSDARG00000096187Danio rerio
 si:dkey-21h14.12ENSDARG00000094603Danio rerio
 si:dkey-21h14.8ENSDARG00000096083Danio rerio
 si:dkey-21h14.9ENSDARG00000096153Danio rerio
 ENSGALG00000046256Gallus gallus
 Cd163ENSMUSG00000008845Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NR16 / CD163L1 / CD163 molecule like 1ENSG0000017767554
DMBT1 / Q9UGM3 / deleted in malignant brain tumors 1ENSG0000018790841
Q4G0T1 / SCART1 / scavenger receptor family member expressed on T cells 1ENSG0000021427931
SSC5D / A1L4H1 / scavenger receptor cysteine rich family member with 5 domainsENSG0000017995425
SSC4D / Q8WTU2 / scavenger receptor cysteine rich family member with 4 domainsENSG0000014670019
P56730 / PRSS12 / serine protease 12ENSG0000016409918
CD5L / O43866 / CD5 molecule likeENSG0000007375412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR017448  SRCR-like domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006954 inflammatory response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 molecular_functionGO:0005044 scavenger receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000257017 HP / P00738 / haptoglobin  / complex / reaction
 ENSG00000188536 HBA2 / P69905 / hemoglobin subunit alpha 2  / complex / reaction
 ENSG00000244734 HBB / P68871 / hemoglobin subunit beta  / complex / reaction






 

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