ENSMUSG00000031138


Mus musculus

Features
Gene ID: ENSMUSG00000031138
  
Biological name :F9
  
Synonyms : Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / F9 / P16294
  
Possible biological names infered from orthology : coagulation factor IX / P00740
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A6
Gene start: 59999464
Gene end: 60030759
  
Corresponding Affymetrix probe sets: 10599826 (MoGene1.0st)   1427393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033477
NCBI entrez gene - 14071     See in Manteia.
MGI - MGI:88384
RefSeq - NM_007979
RefSeq - NM_001305797
RefSeq Peptide - NP_001292726
RefSeq Peptide - NP_032005
swissprot - P16294
Ensembl - ENSMUSG00000031138
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f9aENSDARG00000010097Danio rerio
 f9bENSDARG00000029493Danio rerio
 F9ENSGALG00000006513Gallus gallus
 F9ENSG00000101981Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*ENSMUSG0000003144443
F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*ENSMUSG0000003144339
Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...ENSMUSG0000002438635
Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*ENSMUSG0000003144529
C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000009847029
C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000005517229
Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*ENSMUSG0000002288727
Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...ENSMUSG0000002897925
C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*ENSMUSG0000003852125
C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*ENSMUSG0000007934325
Pamr1 / Q8BU25 / Inactive serine protease PAMR1 / Q6UXH9* / peptidase domain containing associated with muscle regeneration 1*ENSMUSG0000002718822
C1rl / Q3UZ09 / Complement C1r subcomponent-like protein / Q9NZP8* / complement C1r subcomponent like*ENSMUSG0000003852721
Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*ENSMUSG0000003172215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR012224  Peptidase S1A, coagulation factor VII/IX/X/C/Z
 IPR013032  EGF-like, conserved site
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR035694  Coagulation factor IX
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0007596 blood coagulation ISO
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0031638 zymogen activation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: F9tm1Dws/F9tm1Dws
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F9tm1Dws/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F9tm1Dws/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: F9tm1Dws/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: F9tm1Dws/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wt1tm1.1Jak/Wt1tm1.1Jak
Genetic Background: involves: 129S4/SvJae

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: F9tm1Ver/F9tm1Ver
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: F9tm1Dws/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: F9tm1Dws/F9tm1Dws
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F9tm1Ver/F9tm1Ver
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: F9tm1Ver/F9tm1Ver
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: F9tm3Dws/F9tm3Dws
Genetic Background: B6.129P2-F9tm3Dws

Allelic Composition: F9tm1Dws/F9tm1Dws
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F9tm1Dws/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: F9tm1Dws/F9tm1Dws
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F9tm1Dws/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0012305 umbilical cord hemorrhage "bleeding into or from the umbilical cord" [MGI:anna]
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Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031443 F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*  / reaction
 ENSMUSG00000028128 F3 / coagulation factor III, tissue factor / P13726*  / reaction
 ENSMUSG00000031645 F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*  / reaction
 ENSMUSG00000030054 Gp9 / O88186 / glycoprotein 9 (platelet) / P14770* / glycoprotein IX platelet*  / reaction
 ENSMUSG00000031138 F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*  / complex
 ENSMUSG00000031444 F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*  / reaction
 ENSMUSG00000031196 F8 / Q06194 / Coagulation factor VIII / P00451*  / complex / reaction
 ENSMUSG00000050675 Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*  / reaction
 ENSMUSG00000050761 Gp1bb / P56400 / glycoprotein Ib, beta polypeptide / P13224* / glycoprotein Ib platelet beta subunit*  / reaction
 ENSMUSG00000053460 Ggcx / Q9QYC7 / Vitamin K-dependent gamma-carboxylase / P38435* / gamma-glutamyl carboxylase*  / reaction
 ENSMUSG00000047953 Gp5 / glycoprotein V platelet / P40197*  / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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