ENSMUSG00000028128


Mus musculus

Features
Gene ID: ENSMUSG00000028128
  
Biological name :F3
  
Synonyms : coagulation factor III, tissue factor / F3
  
Possible biological names infered from orthology : P13726
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 121723537
Gene end: 121735048
  
Corresponding Affymetrix probe sets: 10495675 (MoGene1.0st)   1417408_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029771
Ensembl peptide - ENSMUSP00000143678
NCBI entrez gene - 14066     See in Manteia.
MGI - MGI:88381
RefSeq - NM_010171
RefSeq Peptide - NP_034301
swissprot - A0A0R4J088
swissprot - A0A0G2JGS5
Ensembl - ENSMUSG00000028128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f3aENSDARG00000099124Danio rerio
 f3bENSDARG00000005673Danio rerio
 ENSGALG00000005619Gallus gallus
 F3ENSG00000117525Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001187  Tissue factor
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR030472  Tissue factor, conserved site
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002541 activation of plasma proteins involved in acute inflammatory response IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:1905286 serine-type peptidase complex IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA


Pathways (from Reactome)
Pathway description
Extrinsic Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: F3tm1Dco/F3tm1Dco
Genetic Background: Not Specified

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Kif18agcd2/Kif18agcd2
Genetic Background: CAST.129S1(B6)-Kif18agcd2/JcsJ

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: F3tm1Dco/F3tm1Dco
Genetic Background: Not Specified

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: F3tm1Dco/F3tm1Dco
Genetic Background: Not Specified

Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: F3tm1Dco/F3tm1Dco
Genetic Background: Not Specified

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Gli3Mos1/Gli3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fat4tm2Hmc/Fat4tm2Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fat4tm2Hmc/Fat4tm2Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F3tm1Dwr/F3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F3tm1Dwr/F3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

Allelic Composition: F3tm1Jld/F3+
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: F3tm1Nmk/F3tm1Nmk,Myl2tm1(cre)Krc/?
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/?
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: F3tm1Dco/F3tm1Dco
Genetic Background: Not Specified

Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: F3tm1Dco/F3tm1Dco
Genetic Background: Not Specified

Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004230 abnormal embryonic erythrocyte morphology "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fat4tm2Hmc/Fat4tm2Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F3tm1Dwr/F3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1Dwr/F3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli3Mos1/Gli3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trotm1Mfu/Y
Genetic Background: involves: 129S2/SvPas

Allelic Composition: F2rtm1Pago/F2rtm1Pago,F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: B6.129-F3tm1.1Dwr F2rtm1Pago

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fat4tm2Hmc/Fat4tm2Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Procrtm1Cte/Procrtm2Cte
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6

Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: F3tm1Dco/F3tm1Dco
Genetic Background: Not Specified

Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: F3tm1Fct/F3tm1Fct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: F3tm1Gjb/F3tm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: F3tm1Dco/F3tm1Dco
Genetic Background: Not Specified

Allelic Composition: F3tm1Jld/F3tm1Jld
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031443 F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*  / reaction / complex
 ENSMUSG00000027082 Tfpi / O54819 / tissue factor pathway inhibitor / P10646*  / complex / reaction
 ENSMUSG00000031138 F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*  / reaction
 ENSMUSG00000031444 F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*  / reaction / complex






 

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