ENSMUSG00000027082


Mus musculus

Features
Gene ID: ENSMUSG00000027082
  
Biological name :Tfpi
  
Synonyms : O54819 / Tfpi / tissue factor pathway inhibitor
  
Possible biological names infered from orthology : P10646
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: D
Gene start: 84432855
Gene end: 84476775
  
Corresponding Affymetrix probe sets: 10484389 (MoGene1.0st)   1438530_at (Mouse Genome 430 2.0 Array)   1451790_a_at (Mouse Genome 430 2.0 Array)   1451791_at (Mouse Genome 430 2.0 Array)   1452432_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107347
Ensembl peptide - ENSMUSP00000107346
Ensembl peptide - ENSMUSP00000107351
Ensembl peptide - ENSMUSP00000122776
Ensembl peptide - ENSMUSP00000028487
Ensembl peptide - ENSMUSP00000088235
Ensembl peptide - ENSMUSP00000107340
Ensembl peptide - ENSMUSP00000107343
NCBI entrez gene - 21788     See in Manteia.
MGI - MGI:1095418
RefSeq - XM_006499150
RefSeq - NM_001177319
RefSeq - NM_001177320
RefSeq - NM_011576
RefSeq - XM_006499145
RefSeq - XM_006499146
RefSeq - XM_006499147
RefSeq - XM_006499148
RefSeq - XM_006499149
RefSeq Peptide - NP_001342202
RefSeq Peptide - NP_035706
RefSeq Peptide - NP_001170790
RefSeq Peptide - NP_001170791
RefSeq Peptide - NP_001342200
swissprot - Q8BSB7
swissprot - A2ARA0
swissprot - A2ARA4
swissprot - A2ARA3
swissprot - O54819
Ensembl - ENSMUSG00000027082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfpiaENSDARG00000034718Danio rerio
 TFPIENSGALG00000002594Gallus gallus
 TFPIENSG00000003436Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tfpi2 / O35536 / tissue factor pathway inhibitor 2 / P48307*ENSMUSG0000002966423
Q9R097 / Spint1 / Kunitz-type protease inhibitor 1 / O43278* / serine peptidase inhibitor, Kunitz type 1*ENSMUSG0000002731520
Q9WU03 / Spint2 / Kunitz-type protease inhibitor 2 / O43291* / serine peptidase inhibitor, Kunitz type 2*ENSMUSG0000007422717
Ambp / Q07456 / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin / P02760* / alpha-1-microglobulin/bikunin precursor*ENSMUSG0000002835616
Q7TQN3 / Wfikkn2 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 / Q8TEU8*ENSMUSG0000004417715
Q8R0S6 / Wfikkn1 / WAP, FS, Ig, KU, and NTR-containing protein 1 / Q96NZ8* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1*ENSMUSG0000007119214
Spint3 / serine peptidase inhibitor, Kunitz type, 3 / P49223*ENSMUSG000000745968


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008296  Tissue factor pathway inhibitor-like
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR029864  Tissue factor pathway inhibitor 1
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030195 negative regulation of blood coagulation ISO
 biological_processGO:0071383 cellular response to steroid hormone stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0009986 cell surface ISO
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Extrinsic Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000084 abnormal fontanelle morphology "structural defect in the membranous interval at the margins of cranial bones in neonates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: F7tm1Pec/F7+,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
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Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: F7tm1Pec/F7+,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tfpitm1.1Rdsi/Tfpitm1.1Rdsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C3H * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tfpitm1.1Rdsi/Tfpitm1.1Rdsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C3H * C57BL/6

Allelic Composition: Tfpitm1.1Rdsi/Tfpitm1.1Rdsi,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Tfpitm1.1Rdsi Tg(Tek-cre)12Flv

Allelic Composition: Tfpitm1.1Rdsi/Tfpitm1.1Rdsi,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0010211 abnormal acute phase protein level "deviation from the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: F7tm1Pec/F7+,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: F7tm1Pec/F7tm1Pec,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Krit1tm1Sfre/Krit1tm1Sfre
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: 129S1(Cg)-F5tm2Dgi

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: 129S1(Cg)-F5tm2Dgi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031443 F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*  / reaction / complex
 ENSMUSG00000028128 F3 / coagulation factor III, tissue factor / P13726*  / reaction / complex
 ENSMUSG00000031444 F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*  / reaction / complex






 

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