ENSMUSG00000028356


Mus musculus

Features
Gene ID: ENSMUSG00000028356
  
Biological name :Ambp
  
Synonyms : Ambp / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin / Q07456
  
Possible biological names infered from orthology : alpha-1-microglobulin/bikunin precursor / P02760
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B3
Gene start: 63143275
Gene end: 63154799
  
Corresponding Affymetrix probe sets: 10513630 (MoGene1.0st)   1416649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030041
Ensembl peptide - ENSMUSP00000118965
NCBI entrez gene - 11699     See in Manteia.
MGI - MGI:88002
RefSeq - NM_007443
RefSeq Peptide - NP_031469
swissprot - I7HIQ9
swissprot - Q07456
Ensembl - ENSMUSG00000028356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ambpENSDARG00000004296Danio rerio
 AMBPENSGALG00000030255Gallus gallus
 AMBPENSG00000106927Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9R097 / Spint1 / Kunitz-type protease inhibitor 1 / O43278* / serine peptidase inhibitor, Kunitz type 1*ENSMUSG0000002731522
Q7TQN3 / Wfikkn2 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 / Q8TEU8*ENSMUSG0000004417719
Q8R0S6 / Wfikkn1 / WAP, FS, Ig, KU, and NTR-containing protein 1 / Q96NZ8* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1*ENSMUSG0000007119217
Q9WU03 / Spint2 / Kunitz-type protease inhibitor 2 / O43291* / serine peptidase inhibitor, Kunitz type 2*ENSMUSG0000007422716
Tfpi / O54819 / tissue factor pathway inhibitor / P10646*ENSMUSG0000002708214
Tfpi2 / O35536 / tissue factor pathway inhibitor 2 / P48307*ENSMUSG0000002966414
Spint3 / serine peptidase inhibitor, Kunitz type, 3 / P49223*ENSMUSG000000745967


Protein motifs (from Interpro)
Interpro ID Name
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR002345  Lipocalin
 IPR002968  Alpha-1-microglobulin
 IPR012674  Calycin
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR022272  Lipocalin family conserved site
 IPR029856  Protein AMBP
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0018298 protein-chromophore linkage IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0051604 protein maturation ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0019862 IgA binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0036094 small molecule binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ambptm1Kkm/Ambptm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ambptm1Kkm/Ambptm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ambptm1Kkm/Ambptm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ambptm1Kkm/Ambptm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ambptm1Kkm/Ambptm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ambptm1Kkm/Ambptm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003697 absent zona pellucida "missing the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009374 failure of cumulus expansion "complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ambptm1Kkm/Ambptm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028356 Ambp / Q07456 / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin / P02760* / alpha-1-microglobulin/bikunin precursor*  / reaction / complex
 ENSMUSG00000067149 Jchain / P01592 / Immunoglobulin J chain / P01591* / joining chain of multimeric IgA and IgM*  / complex






 

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