ENSMUSG00000027315


Mus musculus

Features
Gene ID: ENSMUSG00000027315
  
Biological name :Spint1
  
Synonyms : Kunitz-type protease inhibitor 1 / Q9R097 / Spint1
  
Possible biological names infered from orthology : O43278 / serine peptidase inhibitor, Kunitz type 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119237362
Gene end: 119249527
  
Corresponding Affymetrix probe sets: 10474936 (MoGene1.0st)   1416627_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028783
Ensembl peptide - ENSMUSP00000106440
Ensembl peptide - ENSMUSP00000106441
NCBI entrez gene - 20732     See in Manteia.
MGI - MGI:1338033
RefSeq - NM_016907
RefSeq - XM_006499062
RefSeq Peptide - NP_058603
swissprot - Q9R097
Ensembl - ENSMUSG00000027315
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spint1aENSDARG00000102332Danio rerio
 spint1bENSDARG00000012467Danio rerio
 SPINT1ENSGALG00000008469Gallus gallus
 O43278ENSG00000166145Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7TQN3 / Wfikkn2 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 / Q8TEU8*ENSMUSG0000004417718
Q8R0S6 / Wfikkn1 / WAP, FS, Ig, KU, and NTR-containing protein 1 / Q96NZ8* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1*ENSMUSG0000007119216
Ambp / Q07456 / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin / P02760* / alpha-1-microglobulin/bikunin precursor*ENSMUSG0000002835615
Q9WU03 / Spint2 / Kunitz-type protease inhibitor 2 / O43291* / serine peptidase inhibitor, Kunitz type 2*ENSMUSG0000007422714
Tfpi / O54819 / tissue factor pathway inhibitor / P10646*ENSMUSG0000002708212
Tfpi2 / O35536 / tissue factor pathway inhibitor 2 / P48307*ENSMUSG0000002966411
Spint3 / serine peptidase inhibitor, Kunitz type, 3 / P49223*ENSMUSG000000745965


Protein motifs (from Interpro)
Interpro ID Name
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR011106  Seven cysteines, N-terminal
 IPR013980  MANSC domain
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IGI
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0045687 positive regulation of glial cell differentiation IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IMP
 biological_processGO:0060674 placenta blood vessel development IMP
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
MET Receptor Activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Prss8fr/Prss8+,Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * DBA

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14Gt(XM184)Byg/St14Gt(XM184)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
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Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14Gt(XM184)Byg/St14Gt(XM184)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14Gt(XM184)Byg/St14Gt(XM184)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14Gt(XM184)Byg/St14Gt(XM184)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14Gt(XM184)Byg/St14Gt(XM184)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prss8fr/Prss8fr,Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * DBA

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Prss8fr/Prss8+,Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * DBA

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prss8fr/Prss8+,Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * DBA

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Prss8fr/Prss8+,Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * DBA

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14Gt(XM184)Byg/St14Gt(XM184)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0004265 abnormal placental transport "anomaly in the conveyance of metabolic products and nutrients across the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
Show

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0004560 abnormal chorionic plate morphology "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0009477 small cecum "reduced size of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14Gt(XM184)Byg/St14Gt(XM184)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14Gt(XM184)Byg/St14Gt(XM184)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Spint1tm1Bug/Spint1tm1Bug,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Prss8fr/Prss8+,Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * DBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Prss8fr/Prss8fr,Spint1tm1Bug/Spint1tm1Bug
Genetic Background: involves: 129S6/SvEvTac * DBA

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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