ENSDARG00000012467


Danio rerio

Features
Gene ID: ENSDARG00000012467
  
Biological name :spint1b
  
Synonyms : serine peptidase inhibitor, Kunitz type 1 b / spint1b
  
Possible biological names infered from orthology : Kunitz-type protease inhibitor 1 / O43278 / Q9R097 / serine peptidase inhibitor, Kunitz type 1 / SPINT1
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 3218893
Gene end: 3238110
  
Corresponding Affymetrix probe sets: Dr.10037.1.A1_at (Zebrafish Array)   Dr.10037.2.S1_at (Zebrafish Array)   Dr.18387.1.A1_s_at (Zebrafish Array)   Dr.18387.1.A1_x_at (Zebrafish Array)   Dr.25609.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000006108
NCBI entrez gene - 797346     See in Manteia.
RefSeq - NM_001111223
RefSeq Peptide - NP_001104693
swissprot - F1QXZ6
ZFIN ID - ZDB-GENE-071218-1
Ensembl - ENSDARG00000012467
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPINT1ENSGALG00000008469Gallus gallus
 O43278ENSG00000166145Homo sapiens
 Q9R097ENSMUSG00000027315Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
spint1a / serine peptidase inhibitor, Kunitz type 1 a / O43278* / SPINT1* / serine peptidase inhibitor, Kunitz type 1*ENSDARG0000010233245
spint2 / serine peptidase inhibitor, Kunitz type, 2 / O43291* / Q9WU03* / AC011479.1* / Kunitz-type protease inhibitor 2 *ENSDARG0000006947617
wfikkn2a / info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a / Q8TEU8* / Q7TQN3* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin dom...ENSDARG0000001346017
wfikkn2b / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b / Q7TQN3* / Q8TEU8* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain c...ENSDARG0000005913914
ambp / alpha-1-microglobulin/bikunin precursor / P02760* / Q07456* / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin*ENSDARG0000000429614
wfikkn1 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 / Q96NZ8*ENSDARG0000010136414
tfpia / tissue factor pathway inhibitor a / TFPI* / P10646* / O54819* / tissue factor pathway inhibitor*ENSDARG0000003471810
tfpi2 / tissue factor pathway inhibitor 2 / O35536* / P48307*ENSDARG0000006135110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000601  PKD domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR011106  Seven cysteines, N-terminal
 IPR013783  Immunoglobulin-like fold
 IPR013980  MANSC domain
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008544 epidermis development IGI
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
MET Receptor Activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000329 chorion chorion accumulation keratinocyte , abnormal
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 ZFA:0000554 olfactory epithelium olfactory epithelium morphology , abnormal
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 ZFA:0001180 epidermal basal stratum epidermal basal stratum keratinocyte aggregated , abnormal
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 ZFA:0009158 keratinocyte keratinocyte mislocalised , abnormal
keratinocyte disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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