ENSG00000166145


Homo sapiens

Features
Gene ID: ENSG00000166145
  
Biological name :SPINT1
  
Synonyms : O43278 / serine peptidase inhibitor, Kunitz type 1 / SPINT1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 40844018
Gene end: 40858207
  
Corresponding Affymetrix probe sets: 202826_at (Human Genome U133 Plus 2.0 Array)   235546_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000458074
Ensembl peptide - ENSP00000457076
Ensembl peptide - ENSP00000457284
Ensembl peptide - ENSP00000342098
Ensembl peptide - ENSP00000454315
Ensembl peptide - ENSP00000455038
Ensembl peptide - ENSP00000456015
Ensembl peptide - ENSP00000456769
NCBI entrez gene - 6692     See in Manteia.
OMIM - 605123
RefSeq - XM_011521958
RefSeq - NM_001032367
RefSeq - NM_003710
RefSeq - NM_181642
RefSeq - XM_006720657
RefSeq - XM_011521957
RefSeq Peptide - NP_001027539
RefSeq Peptide - NP_003701
RefSeq Peptide - NP_857593
swissprot - H3BNW5
swissprot - H3BR01
swissprot - H3BSM2
swissprot - H3BTQ8
swissprot - H3BVD9
swissprot - O43278
swissprot - H3BMB6
Ensembl - ENSG00000166145
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spint1aENSDARG00000102332Danio rerio
 spint1bENSDARG00000012467Danio rerio
 SPINT1ENSGALG00000008469Gallus gallus
 Q9R097ENSMUSG00000027315Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TEU8 / WFIKKN2 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2ENSG0000017371417
Q96NZ8 / WFIKKN1 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1ENSG0000012757816
AMBP / P02760 / alpha-1-microglobulin/bikunin precursorENSG0000010692714
O43291 / SPINT2 / serine peptidase inhibitor, Kunitz type 2ENSG0000016764214
TFPI / P10646 / tissue factor pathway inhibitorENSG0000000343613
TFPI2 / P48307 / tissue factor pathway inhibitor 2ENSG0000010582512
AC011479.1ENSG000002677488
P49223 / SPINT3 / serine peptidase inhibitor, Kunitz type 3ENSG000001014465


Protein motifs (from Interpro)
Interpro ID Name
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR011106  Seven cysteines, N-terminal
 IPR013783  Immunoglobulin-like fold
 IPR013980  MANSC domain
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0045687 positive regulation of glial cell differentiation IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IEA
 biological_processGO:0060674 placenta blood vessel development IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
MET Receptor Activation
Signaling by MST1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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