ENSG00000127578


Homo sapiens

Features
Gene ID: ENSG00000127578
  
Biological name :WFIKKN1
  
Synonyms : Q96NZ8 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 / WFIKKN1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 629239
Gene end: 634116
  
Corresponding Affymetrix probe sets: 1552811_at (Human Genome U133 Plus 2.0 Array)   227698_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000324763
NCBI entrez gene - 117166     See in Manteia.
OMIM - 608021
RefSeq - NM_053284
RefSeq Peptide - NP_444514
swissprot - Q96NZ8
Ensembl - ENSG00000127578
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wfikkn1ENSDARG00000101364Danio rerio
 WFIKKN1ENSGALG00000000044Gallus gallus
 Q8R0S6ENSMUSG00000071192Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TEU8 / WFIKKN2 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2ENSG0000017371457
O43278 / SPINT1 / serine peptidase inhibitor, Kunitz type 1ENSG0000016614516
AMBP / P02760 / alpha-1-microglobulin/bikunin precursorENSG0000010692712
O43291 / SPINT2 / serine peptidase inhibitor, Kunitz type 2ENSG0000016764211
TFPI2 / P48307 / tissue factor pathway inhibitor 2ENSG000001058259
TFPI / P10646 / tissue factor pathway inhibitorENSG000000034369
AC011479.1ENSG000002677485
P49223 / SPINT3 / serine peptidase inhibitor, Kunitz type 3ENSG000001014463


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR002350  Kazal domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008197  WAP-type "four-disulfide core" domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR013783  Immunoglobulin-like fold
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR033638  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
 IPR036058  Kazal domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036645  Elafin-like superfamily
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0048747 muscle fiber development IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:1900116 extracellular negative regulation of signal transduction IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0048019 receptor antagonist activity IDA
 molecular_functionGO:0050431 transforming growth factor beta binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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