ENSG00000003436


Homo sapiens

Features
Gene ID: ENSG00000003436
  
Biological name :TFPI
  
Synonyms : P10646 / TFPI / tissue factor pathway inhibitor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q32.1
Gene start: 187464230
Gene end: 187565760
  
Corresponding Affymetrix probe sets: 209676_at (Human Genome U133 Plus 2.0 Array)   210664_s_at (Human Genome U133 Plus 2.0 Array)   210665_at (Human Genome U133 Plus 2.0 Array)   213258_at (Human Genome U133 Plus 2.0 Array)   214378_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388159
Ensembl peptide - ENSP00000386344
Ensembl peptide - ENSP00000394185
Ensembl peptide - ENSP00000409177
Ensembl peptide - ENSP00000408170
Ensembl peptide - ENSP00000402954
Ensembl peptide - ENSP00000400179
Ensembl peptide - ENSP00000233156
Ensembl peptide - ENSP00000342306
Ensembl peptide - ENSP00000376172
NCBI entrez gene - 7035     See in Manteia.
OMIM - 152310
RefSeq - XM_011511709
RefSeq - NM_001032281
RefSeq - NM_001318941
RefSeq - NM_001329240
RefSeq - NM_006287
RefSeq - XM_005246818
RefSeq - XM_005246819
RefSeq - XM_006712720
RefSeq - XM_011511707
RefSeq - XM_011511708
RefSeq Peptide - NP_001305870
RefSeq Peptide - NP_001316168
RefSeq Peptide - NP_001316169
RefSeq Peptide - NP_001316170
RefSeq Peptide - NP_006278
RefSeq Peptide - NP_001027452
swissprot - C9JKV3
swissprot - P10646
swissprot - C9J103
swissprot - C9JT76
swissprot - C9JQ14
swissprot - C9JP39
Ensembl - ENSG00000003436
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfpiaENSDARG00000034718Danio rerio
 TFPIENSGALG00000002594Gallus gallus
 TfpiENSMUSG00000027082Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TFPI2 / P48307 / tissue factor pathway inhibitor 2ENSG0000010582526
O43278 / SPINT1 / serine peptidase inhibitor, Kunitz type 1ENSG0000016614523
O43291 / SPINT2 / serine peptidase inhibitor, Kunitz type 2ENSG0000016764220
AMBP / P02760 / alpha-1-microglobulin/bikunin precursorENSG0000010692717
Q96NZ8 / WFIKKN1 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1ENSG0000012757816
Q8TEU8 / WFIKKN2 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2ENSG0000017371416
AC011479.1ENSG0000026774815
P49223 / SPINT3 / serine peptidase inhibitor, Kunitz type 3ENSG0000010144611


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008296  Tissue factor pathway inhibitor-like
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR029864  Tissue factor pathway inhibitor 1
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0007598 blood coagulation, extrinsic pathway TAS
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030195 negative regulation of blood coagulation IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071383 cellular response to steroid hormone stimulus IEP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity TAS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Extrinsic Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126218 F10 / P00742 / coagulation factor X  / complex / reaction
 ENSG00000117525 F3 / P13726 / coagulation factor III, tissue factor  / complex / reaction
 ENSG00000057593 F7 / P08709 / coagulation factor VII  / complex / reaction






 

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