ENSG00000106927


Homo sapiens

Features
Gene ID: ENSG00000106927
  
Biological name :AMBP
  
Synonyms : alpha-1-microglobulin/bikunin precursor / AMBP / P02760
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q32
Gene start: 114060127
Gene end: 114078472
  
Corresponding Affymetrix probe sets: 205477_s_at (Human Genome U133 Plus 2.0 Array)   214425_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265132
Ensembl peptide - ENSP00000474859
Ensembl peptide - ENSP00000475149
NCBI entrez gene - 259     See in Manteia.
OMIM - 176870
RefSeq - NM_001633
RefSeq Peptide - NP_001624
swissprot - P02760
swissprot - S4R3Y4
swissprot - S4R471
Ensembl - ENSG00000106927
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ambpENSDARG00000004296Danio rerio
 AMBPENSGALG00000030255Gallus gallus
 AmbpENSMUSG00000028356Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43278 / SPINT1 / serine peptidase inhibitor, Kunitz type 1ENSG0000016614521
Q96NZ8 / WFIKKN1 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1ENSG0000012757819
Q8TEU8 / WFIKKN2 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2ENSG0000017371418
O43291 / SPINT2 / serine peptidase inhibitor, Kunitz type 2ENSG0000016764216
TFPI / P10646 / tissue factor pathway inhibitorENSG0000000343615
TFPI2 / P48307 / tissue factor pathway inhibitor 2ENSG0000010582513
AC011479.1ENSG000002677488
P49223 / SPINT3 / serine peptidase inhibitor, Kunitz type 3ENSG000001014467


Protein motifs (from Interpro)
Interpro ID Name
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR002345  Lipocalin
 IPR002968  Alpha-1-microglobulin
 IPR012674  Calycin
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR022272  Lipocalin family conserved site
 IPR029856  Protein AMBP
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007565 female pregnancy NAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0018298 protein-chromophore linkage IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0042167 heme catabolic process NAS
 biological_processGO:0046329 negative regulation of JNK cascade TAS
 biological_processGO:0050777 negative regulation of immune response NAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019855 calcium channel inhibitor activity NAS
 molecular_functionGO:0019862 IgA binding IDA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0036094 small molecule binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046904 calcium oxalate binding NAS


Pathways (from Reactome)
Pathway description
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106927 AMBP / P02760 / alpha-1-microglobulin/bikunin precursor  / reaction / complex
 ENSG00000132465 JCHAIN / P01591 / joining chain of multimeric IgA and IgM  / complex
 ENSG00000211890 IGHA2 / P01877 / immunoglobulin heavy constant alpha 2 (A2m marker)  / complex
 ENSG00000211895 IGHA1 / P01876 / immunoglobulin heavy constant alpha 1  / complex






 

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