ENSG00000211890


Homo sapiens

Features
Gene ID: ENSG00000211890
  
Biological name :IGHA2
  
Synonyms : IGHA2 / immunoglobulin heavy constant alpha 2 (A2m marker) / P01877
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 105583731
Gene end: 105588395
  
Corresponding Affymetrix probe sets: 215118_s_at (Human Genome U133 Plus 2.0 Array)   217022_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000374981
Ensembl peptide - ENSP00000493086
swissprot - A0A286YEY5
swissprot - P01877
Ensembl - ENSG00000211890
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-4ENSDARG00000096355Danio rerio
 IghaENSMUSG00000095079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGHA1 / P01876 / immunoglobulin heavy constant alpha 1ENSG0000021189585
IGHM / P01871 / immunoglobulin heavy constant muENSG0000021189932
IGHG3 / immunoglobulin heavy constant gamma 3 (G3m marker)ENSG0000021189727
IGHE / P01854 / immunoglobulin heavy constant epsilonENSG0000021189126
IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)ENSG0000021189626
IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)ENSG0000021189325
IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)ENSG0000021189225


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001895 retina homeostasis HEP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0003094 glomerular filtration IMP
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006955 immune response NAS
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0060267 positive regulation of respiratory burst IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071748 monomeric IgA immunoglobulin complex IDA
 cellular_componentGO:0071751 secretory IgA immunoglobulin complex IDA
 cellular_componentGO:0071752 secretory dimeric IgA immunoglobulin complex IDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003823 antigen binding TAS
 molecular_functionGO:0034987 immunoglobulin receptor binding IDA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132465 JCHAIN / P01591 / joining chain of multimeric IgA and IgM  / complex
 ENSG00000211895 IGHA1 / P01876 / immunoglobulin heavy constant alpha 1  / complex
 ENSG00000162897 FCAMR / Q8WWV6 / Fc fragment of IgA and IgM receptor  / complex / reaction
 ENSG00000211890 IGHA2 / P01877 / immunoglobulin heavy constant alpha 2 (A2m marker)  / complex
 ENSG00000106927 AMBP / P02760 / alpha-1-microglobulin/bikunin precursor  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr