ENSG00000132465


Homo sapiens

Features
Gene ID: ENSG00000132465
  
Biological name :JCHAIN
  
Synonyms : JCHAIN / joining chain of multimeric IgA and IgM / P01591
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q13.3
Gene start: 70655541
Gene end: 70681817
  
Corresponding Affymetrix probe sets: 212592_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427112
Ensembl peptide - ENSP00000417560
Ensembl peptide - ENSP00000440066
Ensembl peptide - ENSP00000426045
Ensembl peptide - ENSP00000426687
Ensembl peptide - ENSP00000254801
NCBI entrez gene - 3512     See in Manteia.
OMIM - 147790
RefSeq - XM_006714211
RefSeq - XM_006714212
RefSeq - XM_011531925
RefSeq - XM_011531926
RefSeq - NM_144646
RefSeq Peptide - NP_653247
swissprot - P01591
swissprot - D6RD17
swissprot - C9JA05
swissprot - D6RHJ6
Ensembl - ENSG00000132465
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JCHAINENSGALG00000011551Gallus gallus
 JchainENSMUSG00000067149Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024110  Immunoglobulin J chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001895 retina homeostasis HEP
 biological_processGO:0002250 adaptive immune response IDA
 biological_processGO:0003094 glomerular filtration IMP
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006955 immune response NAS
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0032461 positive regulation of protein oligomerization IMP
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0060267 positive regulation of respiratory burst IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071748 monomeric IgA immunoglobulin complex IDA
 cellular_componentGO:0071750 dimeric IgA immunoglobulin complex IMP
 cellular_componentGO:0071751 secretory IgA immunoglobulin complex IDA
 cellular_componentGO:0071752 secretory dimeric IgA immunoglobulin complex IDA
 cellular_componentGO:0071756 pentameric IgM immunoglobulin complex IDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003823 antigen binding NAS
 molecular_functionGO:0019862 IgA binding IMP
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IDA
 molecular_functionGO:0034987 immunoglobulin receptor binding IMP
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0042834 peptidoglycan binding IDA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162897 FCAMR / Q8WWV6 / Fc fragment of IgA and IgM receptor  / complex / reaction
 ENSG00000106927 AMBP / P02760 / alpha-1-microglobulin/bikunin precursor  / complex
 ENSG00000211890 IGHA2 / P01877 / immunoglobulin heavy constant alpha 2 (A2m marker)  / complex
 ENSG00000211895 IGHA1 / P01876 / immunoglobulin heavy constant alpha 1  / complex






 

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