ENSMUSG00000067149


Mus musculus

Features
Gene ID: ENSMUSG00000067149
  
Biological name :Jchain
  
Synonyms : Immunoglobulin J chain / Jchain / P01592
  
Possible biological names infered from orthology : joining chain of multimeric IgA and IgM / P01591
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E1
Gene start: 88519809
Gene end: 88527891
  
Corresponding Affymetrix probe sets: 10531126 (MoGene1.0st)   1424305_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084259
NCBI entrez gene - 16069     See in Manteia.
MGI - MGI:96493
RefSeq - NM_152839
RefSeq Peptide - NP_690052
swissprot - P01592
Ensembl - ENSMUSG00000067149
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JCHAINENSGALG00000011551Gallus gallus
 JCHAINENSG00000132465Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024110  Immunoglobulin J chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0003094 glomerular filtration IEA
 biological_processGO:0006959 humoral immune response ISS
 biological_processGO:0019731 antibacterial humoral response IEA
 biological_processGO:0032461 positive regulation of protein oligomerization IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0060267 positive regulation of respiratory burst IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0071748 monomeric IgA immunoglobulin complex IEA
 cellular_componentGO:0071750 dimeric IgA immunoglobulin complex IMP
 cellular_componentGO:0071751 secretory IgA immunoglobulin complex IEA
 cellular_componentGO:0071752 secretory dimeric IgA immunoglobulin complex IEA
 cellular_componentGO:0071756 pentameric IgM immunoglobulin complex IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003823 antigen binding ISS
 molecular_functionGO:0019862 IgA binding IDA
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0031210 phosphatidylcholine binding IEA
 molecular_functionGO:0034987 immunoglobulin receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042834 peptidoglycan binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Jchaintm2(Myc)Tl/Jchaintm2(Myc)Tl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

Allelic Composition: Jchaintm1Tl/Jchaintm1Tl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jchaintm1Tl/Jchaintm1Tl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jchaintm1Jse/Jchaintm1Jse
Genetic Background: involves: 129X1/SvJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jchaintm1Jse/Jchaintm1Jse
Genetic Background: involves: 129X1/SvJ

 MP:0002473 impaired complement classical pathway "abnormal function of the plasma protein cascade triggered by antigen:antibody complexes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbn1Tsk/Fbn1+
Genetic Background: B6.Cg-Fbn1Tsk

Allelic Composition: Jchaintm3Tl/Jchaintm3Tl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jchaintm1Tl/Jchaintm1Tl
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Jchaintm1Jse/Jchaintm1Jse
Genetic Background: involves: 129X1/SvJ

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jchaintm1Jse/Jchaintm1Jse
Genetic Background: involves: 129X1/SvJ

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jchaintm1Jse/Jchaintm1Jse
Genetic Background: involves: 129X1/SvJ

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jchaintm1Jse/Jchaintm1Jse
Genetic Background: involves: 129X1/SvJ

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jchaintm3Tl/Jchaintm3Tl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008864 abnormal intestinal secretion "any anomaly in the quantity or rate of any substance transported from intestinal cells into the lumen of the intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jchaintm1Jse/Jchaintm1Jse
Genetic Background: involves: 129X1/SvJ

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jchaintm1Jse/Jchaintm1Jse
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026415 Fcamr / Q2TB54 / High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor / Q8WWV6* / Fc fragment of IgA and IgM receptor*  / reaction / complex
 ENSMUSG00000028356 Ambp / Q07456 / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin / P02760* / alpha-1-microglobulin/bikunin precursor*  / complex






 

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