ENSMUSG00000026415


Mus musculus

Features
Gene ID: ENSMUSG00000026415
  
Biological name :Fcamr
  
Synonyms : Fcamr / High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor / Q2TB54
  
Possible biological names infered from orthology : Fc fragment of IgA and IgM receptor / Q8WWV6
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 130800902
Gene end: 130814740
  
Corresponding Affymetrix probe sets: 10349571 (MoGene1.0st)   1425925_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027670
Ensembl peptide - ENSMUSP00000108096
NCBI entrez gene - 64435     See in Manteia.
MGI - MGI:1927803
RefSeq - XM_017321925
RefSeq - NM_001170632
RefSeq - NM_144960
RefSeq - XM_017321922
RefSeq - XM_017321923
RefSeq - XM_017321924
RefSeq - XM_006529787
RefSeq - XM_011248055
RefSeq - XM_017321921
RefSeq Peptide - NP_659209
RefSeq Peptide - NP_001164103
swissprot - Q2TB54
Ensembl - ENSMUSG00000026415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FCAMRENSG00000162897Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pigr / O70570 / Polymeric immunoglobulin receptor Secretory component / P01833* / polymeric immunoglobulin receptor*ENSMUSG0000002641715
Fcmr / Fc fragment of IgM receptor / O60667*ENSMUSG0000004247410


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001791 IgM binding IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0019862 IgA binding IDA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

 MP:0008095 abnormal memory B cell differentiation "atypical production of or inability to produce distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

 MP:0008193 abnormal marginal zone B cell physiology "abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0008198 abnormal follicular dendritic cell antigen presentation "anomaly in the ability of follicular dendritic cells to process and present antigen to B lymphocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Oprm1tm1Jabl/Oprm1tm1Jabl
Genetic Background: C57BL/6-Oprm1tm1Jabl

Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000067149 Jchain / P01592 / Immunoglobulin J chain / P01591* / joining chain of multimeric IgA and IgM*  / reaction / complex






 

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