| MP:0000642 | enlarged adrenal glands | "increased size of the endocrine gland" [J:40203] |
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay
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| MP:0001806 | decreased IgM | "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Fcmrtm1Mak/Fcmrtm1Mak
Genetic Background: B6.129S2-Fcmrtm1Mak
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| MP:0002462 | abnormal granulocyte physiology | "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified
Allelic Composition: Fcmrtm1Mak/Fcmrtm1Mak
Genetic Background: B6.129S2-Fcmrtm1Mak
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| MP:0002490 | abnormal circulating immunoglobulin concentration | "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0002494 | increased IgM | "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0002942 | decreased circulating alanine transaminase level | "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified
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| MP:0003009 | abnormal cytokine secretion | "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Fcmrtm1Mak/Fcmrtm1Mak
Genetic Background: B6.129S2-Fcmrtm1Mak
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| MP:0004762 | increased anti-double stranded DNA antibody level | "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0004829 | increased anti-chromatin antibody level | "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0004939 | abnormal B cell morphology | "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0004977 | increased B-1 B cell number | "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0005015 | increased T cell number | "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified
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| MP:0005025 | response to infection | "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0005074 | defective granulocyte bactericidal activity | "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5405] |
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Allelic Composition: Fcmrtm1Mak/Fcmrtm1Mak
Genetic Background: B6.129S2-Fcmrtm1Mak
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| MP:0005166 | decreased susceptiblity to injury | "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified
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| MP:0006413 | increased T cell apoptosis | "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified
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| MP:0008182 | decreased marginal zone B cell number | "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0008495 | decreased IgG1 level | "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0008502 | increased IgG3 level | "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0008561 | decreased tumor necrosis factor secretion | "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Fcmrtm1Mak/Fcmrtm1Mak
Genetic Background: B6.129S2-Fcmrtm1Mak
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| MP:0008706 | decreased interleukin-6 secretion | "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Fcmrtm1Mak/Fcmrtm1Mak
Genetic Background: B6.129S2-Fcmrtm1Mak
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| MP:0009767 | decreased sensitivity to xenobiotic induced morbidity/mortality | "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified
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| MP:0009788 | increased susceptibility to bacterial infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fcmrtm1Mak/Fcmrtm1Mak
Genetic Background: B6.129S2-Fcmrtm1Mak
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| MP:0009789 | decreased susceptibility to bacterial infection induced morbidity/mortality | "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fcmrtm1Mak/Fcmrtm1Mak
Genetic Background: B6.129S2-Fcmrtm1Mak
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