ENSMUSG00000026417


Mus musculus

Features
Gene ID: ENSMUSG00000026417
  
Biological name :Pigr
  
Synonyms : O70570 / Pigr / Polymeric immunoglobulin receptor Secretory component
  
Possible biological names infered from orthology : P01833 / polymeric immunoglobulin receptor
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 130826684
Gene end: 130852249
  
Corresponding Affymetrix probe sets: 10349580 (MoGene1.0st)   1450060_at (Mouse Genome 430 2.0 Array)   1455490_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027675
Ensembl peptide - ENSMUSP00000121686
Ensembl peptide - ENSMUSP00000114334
NCBI entrez gene - 18703     See in Manteia.
MGI - MGI:103080
RefSeq - NM_011082
RefSeq Peptide - NP_035212
swissprot - D3Z2D3
swissprot - D3YVM4
swissprot - O70570
Ensembl - ENSMUSG00000026417
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIGRENSGALG00000000919Gallus gallus
 PIGRENSG00000162896Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcamr / Q2TB54 / High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor / Q8WWV6* / Fc fragment of IgA and IgM receptor*ENSMUSG0000002641511
Fcmr / Fc fragment of IgM receptor / O60667*ENSMUSG000000424748


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IEA
 biological_processGO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0038093 Fc receptor signaling pathway IEA
 biological_processGO:0043113 receptor clustering IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0001792 polymeric immunoglobulin receptor activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

 MP:0000501 abnormal digestive secretion "malfunction of the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Jchaintm1Jse/Jchaintm1Jse
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Pigrtm1Fejo/Pigr+
Genetic Background: involves: 129 * C57BL/6

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

Allelic Composition: Pigrtm1Rast/Pigrtm1Rast
Genetic Background: C57BL/6-Pigrtm1Rast

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: B6.129X1-Pigrtm1Ohw

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-Ab1tm1Hpl/H2-Ab1+
Genetic Background: involves: 129S4/SvJae

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

Allelic Composition: Pigrtm1Rast/Pigrtm1Rast
Genetic Background: C57BL/6-Pigrtm1Rast

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

Allelic Composition: Pigrtm1Rast/Pigrtm1Rast
Genetic Background: C57BL/6-Pigrtm1Rast

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

Allelic Composition: Pigrtm1Rast/Pigrtm1Rast
Genetic Background: C57BL/6-Pigrtm1Rast

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: B6.129X1-Pigrtm1Ohw

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Pigrtm1Fejo/Pigrtm1Fejo
Genetic Background: involves: 129 * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: B6.129X1-Pigrtm1Ohw

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pigrtm1Fejo/Pigrtm1Fejo
Genetic Background: involves: 129 * C57BL/6

 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
Show

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: B6.129X1-Pigrtm1Ohw

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: B6.129X1-Pigrtm1Ohw

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: B6.129X1-Pigrtm1Ohw

 MP:0008895 abnormal intraepithelial T cell number "reduced number of T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
Show

Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw
Genetic Background: B6.129X1-Pigrtm1Ohw

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

 MP:0010223 abnormal immunoglobulin transcytosis "any anomaly in the process of transporting immunoglobulin, via transcytosis, from one side of a cell to the other; occurs in epithelial cells and other cell types" [GO:0002414, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttntm1Her/Ttntm1Her
Genetic Background: Not Specified

Allelic Composition: Pigrtm1Rast/Pigrtm1Rast
Genetic Background: C57BL/6-Pigrtm1Rast

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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