ENSG00000117525


Homo sapiens

Features
Gene ID: ENSG00000117525
  
Biological name :F3
  
Synonyms : coagulation factor III, tissue factor / F3 / P13726
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p21.3
Gene start: 94529225
Gene end: 94541800
  
Corresponding Affymetrix probe sets: 204363_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000334145
Ensembl peptide - ENSP00000359226
NCBI entrez gene - 2152     See in Manteia.
OMIM - 134390
RefSeq - NM_001178096
RefSeq - NM_001993
RefSeq Peptide - NP_001171567
RefSeq Peptide - NP_001984
swissprot - P13726
Ensembl - ENSG00000117525
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f3aENSDARG00000099124Danio rerio
 f3bENSDARG00000005673Danio rerio
 ENSGALG00000005619Gallus gallus
 F3ENSMUSG00000028128Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001187  Tissue factor
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR030472  Tissue factor, conserved site
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IDA
 biological_processGO:0002541 activation of plasma proteins involved in acute inflammatory response IDA
 biological_processGO:0002543 activation of blood coagulation via clotting cascade IC
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0007596 blood coagulation IDA
 biological_processGO:0007598 blood coagulation, extrinsic pathway TAS
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway IDA
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0030335 positive regulation of cell migration TAS
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0050927 positive regulation of positive chemotaxis IC
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0031233 intrinsic component of external side of plasma membrane IC
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1905286 serine-type peptidase complex IPI
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0004896 cytokine receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA


Pathways (from Reactome)
Pathway description
Extrinsic Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000003436 TFPI / P10646 / tissue factor pathway inhibitor  / complex / reaction
 ENSG00000057593 F7 / P08709 / coagulation factor VII  / reaction / complex
 ENSG00000101981 F9 / P00740 / coagulation factor IX  / reaction
 ENSG00000126218 F10 / P00742 / coagulation factor X  / complex / reaction






 

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