ENSDARG00000102332


Danio rerio

Features
Gene ID: ENSDARG00000102332
  
Biological name :spint1a
  
Synonyms : serine peptidase inhibitor, Kunitz type 1 a / spint1a
  
Possible biological names infered from orthology : Kunitz-type protease inhibitor 1 / O43278 / Q9R097 / serine peptidase inhibitor, Kunitz type 1 / SPINT1
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 1998041
Gene end: 2039511
  
Corresponding Affymetrix probe sets: Dr.3549.1.S1_at (Zebrafish Array)   NM_213152_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000149335
Ensembl peptide - ENSDARP00000156699
Ensembl peptide - ENSDARP00000136123
Ensembl peptide - ENSDARP00000147769
NCBI entrez gene - 406426     See in Manteia.
RefSeq - NM_213152
RefSeq Peptide - NP_998317
swissprot - A0A0G2KUL6
ZFIN ID - ZDB-GENE-040426-2169
Ensembl - ENSDARG00000102332
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPINT1ENSGALG00000008469Gallus gallus
 O43278ENSG00000166145Homo sapiens
 Q9R097ENSMUSG00000027315Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
spint1b / serine peptidase inhibitor, Kunitz type 1 b / O43278* / Q9R097* / SPINT1* / Kunitz-type protease inhibitor 1 * / serine peptidase inhibitor, Kunitz type 1*ENSDARG0000001246743
spint2 / serine peptidase inhibitor, Kunitz type, 2 / O43291* / Q9WU03* / AC011479.1* / Kunitz-type protease inhibitor 2 *ENSDARG0000006947617
wfikkn2a / info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a / Q8TEU8* / Q7TQN3* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin dom...ENSDARG0000001346015
wfikkn1 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 / Q96NZ8*ENSDARG0000010136413
wfikkn2b / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b / Q7TQN3* / Q8TEU8* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain c...ENSDARG0000005913912
ambp / alpha-1-microglobulin/bikunin precursor / P02760* / Q07456* / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin*ENSDARG0000000429611
tfpia / tissue factor pathway inhibitor a / TFPI* / P10646* / O54819* / tissue factor pathway inhibitor*ENSDARG0000003471811
tfpi2 / tissue factor pathway inhibitor 2 / O35536* / P48307*ENSDARG0000006135111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000601  PKD domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR011106  Seven cysteines, N-terminal
 IPR013783  Immunoglobulin-like fold
 IPR013980  MANSC domain
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR022409  PKD/Chitinase domain
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
MET Receptor Activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000040 median fin fold median fin fold morphology , abnormal
median fin fold decreased thickness , abnormal
median fin fold degenerate , abnormal
Show

 ZFA:0000105 epidermis epidermis aggregated , abnormal
epidermis disorganized , abnormal
epidermis increased thickness , abnormal
Show

 ZFA:0000106 extension extension degenerate , abnormal
Show

 ZFA:0000107 eye eye decreased distance eye , abnormal
eye decreased size , abnormal
Show

 ZFA:0000108 fin fin decreased size , abnormal
fin rough , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000329 chorion chorion accumulation keratinocyte , abnormal
Show

 ZFA:0000554 olfactory epithelium olfactory epithelium morphology , abnormal
Show

 ZFA:0001058 caudal fin caudal fin collagen network disorganized , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001115 trunk trunk decreased size , abnormal
Show

 ZFA:0001180 epidermal basal stratum epidermal basal stratum keratinocyte aggregated , abnormal
Show

 ZFA:0001486 epithelium epithelium protruding , abnormal
epithelium neutrophil increased amount , abnormal
Show

 ZFA:0009141 macrophage macrophage mislocalised , abnormal
Show

 ZFA:0009158 keratinocyte keratinocyte mislocalised , abnormal
keratinocyte disorganized , abnormal
Show

 ZFA:0009309 leukocyte leukocyte aggregated , abnormal
Show

 ZFA:0009327 neutrophil neutrophil increased amount , abnormal
neutrophil mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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