ENSDARG00000061351


Danio rerio

Features
Gene ID: ENSDARG00000061351
  
Biological name :tfpi2
  
Synonyms : tfpi2 / tissue factor pathway inhibitor 2
  
Possible biological names infered from orthology : O35536 / P48307
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 40848109
Gene end: 40855106
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000081855
NCBI entrez gene - 560339     See in Manteia.
RefSeq - NM_001040096
RefSeq Peptide - NP_001035185
swissprot - Q1WCN6
ZFIN ID - ZDB-GENE-060503-38
Ensembl - ENSDARG00000061351
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TFPI2ENSGALG00000009512Gallus gallus
 TFPI2ENSG00000105825Homo sapiens
 Tfpi2ENSMUSG00000029664Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tfpia / tissue factor pathway inhibitor a / TFPI* / P10646* / O54819* / tissue factor pathway inhibitor*ENSDARG0000003471832
spint2 / serine peptidase inhibitor, Kunitz type, 2 / O43291* / Q9WU03* / AC011479.1* / Kunitz-type protease inhibitor 2 *ENSDARG0000006947628
spint1a / serine peptidase inhibitor, Kunitz type 1 a / O43278* / SPINT1* / serine peptidase inhibitor, Kunitz type 1*ENSDARG0000010233224
spint1b / serine peptidase inhibitor, Kunitz type 1 b / O43278* / Q9R097* / SPINT1* / Kunitz-type protease inhibitor 1 * / serine peptidase inhibitor, Kunitz type 1*ENSDARG0000001246722
wfikkn2a / info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a / Q8TEU8* / Q7TQN3* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin dom...ENSDARG0000001346018
wfikkn1 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 / Q96NZ8*ENSDARG0000010136417
ambp / alpha-1-microglobulin/bikunin precursor / P02760* / Q07456* / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin*ENSDARG0000000429617
wfikkn2b / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b / Q7TQN3* / Q8TEU8* / WFIKKN2* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain c...ENSDARG0000005913917


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:1903706 regulation of hemopoiesis IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary malformed , abnormal
midbrain hindbrain boundary nerve sparse , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000084 yolk yolk increased size , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle decreased size , abnormal
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 ZFA:0000114 heart heart malformed , abnormal
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 ZFA:0000152 retina retina photoreceptor cell disorganized , abnormal
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 ZFA:0000161 third ventricle third ventricle decreased size , abnormal
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 ZFA:0000471 atrium atrium dilated , abnormal
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 ZFA:0001094 whole organism whole organism decreased pigmentation , abnormal
whole organism decreased length , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal malformed , abnormal
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 ZFA:0009147 glial cell (sensu Vertebrata) glial cell (sensu Vertebrata) decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte hemoglobin complex decreased amount , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell sarcomere disorganized , abnormal
cardiac muscle cell Z disc disorganized , abnormal
cardiac muscle cell sarcomere organization disrupted , abnormal
cardiac muscle cell cardiac myofibril decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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