ENSMUSG00000074227


Mus musculus

Features
Gene ID: ENSMUSG00000074227
  
Biological name :Spint2
  
Synonyms : Kunitz-type protease inhibitor 2 / Q9WU03 / Spint2
  
Possible biological names infered from orthology : O43291 / serine peptidase inhibitor, Kunitz type 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 29256323
Gene end: 29281912
  
Corresponding Affymetrix probe sets: 10561712 (MoGene1.0st)   1438968_x_at (Mouse Genome 430 2.0 Array)   1451935_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096204
Ensembl peptide - ENSMUSP00000103871
Ensembl peptide - ENSMUSP00000146580
NCBI entrez gene - 20733     See in Manteia.
MGI - MGI:1338031
RefSeq - XM_017322072
RefSeq - NM_001082548
RefSeq - NM_011464
RefSeq Peptide - NP_035594
RefSeq Peptide - NP_001076017
swissprot - Q9WU03
Ensembl - ENSMUSG00000074227
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spint2ENSDARG00000069476Danio rerio
 O43291ENSG00000167642Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9R097 / Spint1 / Kunitz-type protease inhibitor 1 / O43278* / serine peptidase inhibitor, Kunitz type 1*ENSMUSG0000002731527
Ambp / Q07456 / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin / P02760* / alpha-1-microglobulin/bikunin precursor*ENSMUSG0000002835622
Q7TQN3 / Wfikkn2 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 / Q8TEU8*ENSMUSG0000004417721
Tfpi / O54819 / tissue factor pathway inhibitor / P10646*ENSMUSG0000002708221
Q8R0S6 / Wfikkn1 / WAP, FS, Ig, KU, and NTR-containing protein 1 / Q96NZ8* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1*ENSMUSG0000007119221
Tfpi2 / O35536 / tissue factor pathway inhibitor 2 / P48307*ENSMUSG0000002966420
Spint3 / serine peptidase inhibitor, Kunitz type, 3 / P49223*ENSMUSG0000007459611


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0007163 establishment or maintenance of cell polarity IMP
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0060672 epithelial cell morphogenesis involved in placental branching IMP
 biological_processGO:0071711 basement membrane organization IMP
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:2000146 negative regulation of cell motility IEA
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
MET Receptor Activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Prss8Gt(IST10122F12)Tigm/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Prss8fr/Prss8fr,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg
Genetic Background: involves: 129P2/OlaHsd * DBA

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prss8Gt(IST10122F12)Tigm/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Prss8Gt(IST10122F12)Tigm/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Prss8fr/Prss8+,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg
Genetic Background: involves: 129P2/OlaHsd * DBA

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Prss8Gt(IST10122F12)Tigm/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Prss8fr/Prss8fr,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg
Genetic Background: involves: 129P2/OlaHsd * DBA

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Prss8Gt(IST10122F12)Tigm/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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