ENSMUSG00000044177


Mus musculus

Features
Gene ID: ENSMUSG00000044177
  
Biological name :Wfikkn2
  
Synonyms : Q7TQN3 / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 / Wfikkn2
  
Possible biological names infered from orthology : Q8TEU8
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 94235956
Gene end: 94246005
  
Corresponding Affymetrix probe sets: 10389877 (MoGene1.0st)   10389879 (MoGene1.0st)   1428811_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053238
NCBI entrez gene - 278507     See in Manteia.
MGI - MGI:2669209
RefSeq - XM_011249063
RefSeq - NM_181819
RefSeq - XM_006533501
RefSeq - XM_006533502
RefSeq - XM_006533497
RefSeq - XM_006533498
RefSeq - XM_006533499
RefSeq - XM_006533500
RefSeq Peptide - NP_861540
swissprot - Q7TQN3
Ensembl - ENSMUSG00000044177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wfikkn2aENSDARG00000013460Danio rerio
 wfikkn2bENSDARG00000059139Danio rerio
 WFIKKN2ENSGALG00000007367Gallus gallus
 Q8TEU8ENSG00000173714Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R0S6 / Wfikkn1 / WAP, FS, Ig, KU, and NTR-containing protein 1 / Q96NZ8* / WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1*ENSMUSG0000007119252
Q9R097 / Spint1 / Kunitz-type protease inhibitor 1 / O43278* / serine peptidase inhibitor, Kunitz type 1*ENSMUSG0000002731516
Ambp / Q07456 / Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin / P02760* / alpha-1-microglobulin/bikunin precursor*ENSMUSG0000002835612
Q9WU03 / Spint2 / Kunitz-type protease inhibitor 2 / O43291* / serine peptidase inhibitor, Kunitz type 2*ENSMUSG000000742279
Tfpi2 / O35536 / tissue factor pathway inhibitor 2 / P48307*ENSMUSG000000296648
Tfpi / O54819 / tissue factor pathway inhibitor / P10646*ENSMUSG000000270828
Spint3 / serine peptidase inhibitor, Kunitz type, 3 / P49223*ENSMUSG000000745963


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR002350  Kazal domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008197  WAP-type "four-disulfide core" domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR018933  Netrin module, non-TIMP type
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR033639  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
 IPR036058  Kazal domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036645  Elafin-like superfamily
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IGI
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0048747 muscle fiber development IMP
 biological_processGO:0060021 roof of mouth development IGI
 biological_processGO:1900116 extracellular negative regulation of signal transduction IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0048019 receptor antagonist activity IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003358 abnormal hypaxial muscle morphology "malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004650 increased lumbar vertebrae number "increased number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
Show

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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