ENSMUSG00000050675


Mus musculus

Features
Gene ID: ENSMUSG00000050675
  
Biological name :Gp1ba
  
Synonyms : glycoprotein 1b, alpha polypeptide / Gp1ba / O35930
  
Possible biological names infered from orthology : glycoprotein Ib platelet alpha subunit / P07359
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 70639122
Gene end: 70642036
  
Corresponding Affymetrix probe sets: 10377924 (MoGene1.0st)   1422316_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104191
Ensembl peptide - ENSMUSP00000057563
NCBI entrez gene - 14723     See in Manteia.
MGI - MGI:1333744
RefSeq - NM_010326
RefSeq - XM_006532232
RefSeq Peptide - NP_034456
swissprot - A2CFB8
swissprot - O35930
Ensembl - ENSMUSG00000050675
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GP1BAENSG00000185245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Flrt2 / Q8BLU0 / Leucine-rich repeat transmembrane protein FLRT2 / O43155* / fibronectin leucine rich transmembrane protein 2*ENSMUSG0000004741416
Flrt3 / Q8BGT1 / Leucine-rich repeat transmembrane protein FLRT3 / Q9NZU0* / fibronectin leucine rich transmembrane protein 3*ENSMUSG0000005137916
Flrt1 / Q6RKD8 / Leucine-rich repeat transmembrane protein FLRT1 / Q9NZU1* / fibronectin leucine rich transmembrane protein 1*ENSMUSG0000004778715
Lrg1 / leucine rich alpha-2-glycoprotein 1 / P02750*ENSMUSG0000003709513
Omg / oligodendrocyte myelin glycoprotein / P23515*ENSMUSG0000004961211
Nepn / Q9CQ76 / Nephrocan ENSMUSG0000003862410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007596 blood coagulation ISO
 biological_processGO:0007599 hemostasis IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0042730 fibrinolysis ISO
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gp1baPlt17/Gp1ba+
Genetic Background: involves: BALB/c

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0030025 giant platelets "presence of abnormally enlarged platelets that are as large as or larger than the red blood cells in the microscopic field; giant platelets may be seen in myeloproliferative and myelodysplastic conditions, autoimmune thrombocytopenia, in association with severe leukemoid reactions, and in rare inherited conditions such as Bernard-Soulier syndrome" [HP:0001902, https://www.labce.com/spg498392_giant_platelets.aspx]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021492 F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*  / reaction
 ENSMUSG00000031328 Flna / Q8BTM8 / Filamin-A / P21333*  / complex / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / complex / reaction
 ENSMUSG00000030054 Gp9 / O88186 / glycoprotein 9 (platelet) / P14770* / glycoprotein IX platelet*  / complex
 ENSMUSG00000031138 F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*  / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / complex / reaction
 ENSMUSG00000031645 F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*  / complex / reaction
 ENSMUSG00000050675 Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000050761 Gp1bb / P56400 / glycoprotein Ib, beta polypeptide / P13224* / glycoprotein Ib platelet beta subunit*  / complex
 ENSMUSG00000047953 Gp5 / glycoprotein V platelet / P40197*  / complex






 

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