ENSMUSG00000031328


Mus musculus

Features
Gene ID: ENSMUSG00000031328
  
Biological name :Flna
  
Synonyms : Filamin-A / Flna / Q8BTM8
  
Possible biological names infered from orthology : P21333
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.3
Gene start: 74223461
Gene end: 74249820
  
Corresponding Affymetrix probe sets: 10605256 (MoGene1.0st)   1426677_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121082
Ensembl peptide - ENSMUSP00000117324
Ensembl peptide - ENSMUSP00000123278
Ensembl peptide - ENSMUSP00000033699
Ensembl peptide - ENSMUSP00000098997
Ensembl peptide - ENSMUSP00000109938
Ensembl peptide - ENSMUSP00000114827
Ensembl peptide - ENSMUSP00000116758
NCBI entrez gene - 192176     See in Manteia.
MGI - MGI:95556
RefSeq - XM_017318433
RefSeq - NM_001290421
RefSeq - NM_010227
RefSeq - XM_006527911
RefSeq - XM_011247549
RefSeq Peptide - NP_001277350
RefSeq Peptide - NP_034357
swissprot - B7FAU9
swissprot - F6XC15
swissprot - F6Z2C0
swissprot - F7AVL7
swissprot - B7FAV1
swissprot - J3JS91
swissprot - Q8BTM8
Ensembl - ENSMUSG00000031328
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flnaENSDARG00000074201Danio rerio
 FLNAENSG00000196924Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Flnc / Q8VHX6 / Filamin-C / Q14315*ENSMUSG0000006869972
Flnb / Q80X90 / Filamin-B / O75369*ENSMUSG0000002527868
Syne2 / Q6ZWQ0 / spectrin repeat containing, nuclear envelope 2 / Q8WXH0* / spectrin repeat containing nuclear envelope protein 2*ENSMUSG0000006345016
Clmn / Q8C5W0 / Calmin / Q96JQ2*ENSMUSG000000210977
Syne1 / Q6ZWR6 / Mus musculus spectrin repeat containing, nuclear envelope 1 (Syne1), transcript variant 5, mRNA. / Q8NF91* / spectrin repeat containing nuclear envelope protein 1*ENSMUSG000000960546


Protein motifs (from Interpro)
Interpro ID Name
 IPR001298  Filamin/ABP280 repeat
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR017868  Filamin/ABP280 repeat-like
 IPR028559  Filamin A
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IGI
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway ISS
 biological_processGO:0010977 negative regulation of neuron projection development IGI
 biological_processGO:0016479 negative regulation of transcription by RNA polymerase I ISO
 biological_processGO:0021943 formation of radial glial scaffolds IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030036 actin cytoskeleton organization IGI
 biological_processGO:0030334 regulation of cell migration ISS
 biological_processGO:0031532 actin cytoskeleton reorganization ISO
 biological_processGO:0032231 regulation of actin filament bundle assembly IMP
 biological_processGO:0034394 protein localization to cell surface ISS
 biological_processGO:0042177 negative regulation of protein catabolic process ISS
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043113 receptor clustering ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:0045022 early endosome to late endosome transport IDA
 biological_processGO:0045184 establishment of protein localization ISS
 biological_processGO:0045216 cell-cell junction organization IMP
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0051220 cytoplasmic sequestering of protein ISS
 biological_processGO:0051764 actin crosslink formation ISO
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:0071526 semaphorin-plexin signaling pathway IGI
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090307 mitotic spindle assembly ISO
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading ISO
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IMP
 biological_processGO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential IC
 biological_processGO:1905031 regulation of membrane repolarization during cardiac muscle cell action potential IMP
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IEA
 biological_processGO:2001046 positive regulation of integrin-mediated signaling pathway ISO
 biological_processGO:2001224 positive regulation of neuron migration IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0031523 Myb complex ISO
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0032432 actin filament bundle IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097440 apical dendrite IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity ISS
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0015459 potassium channel regulator activity IMP
 molecular_functionGO:0017048 Rho GTPase binding ISS
 molecular_functionGO:0017160 Ral GTPase binding ISO
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0031267 small GTPase binding ISO
 molecular_functionGO:0031852 mu-type opioid receptor binding IEA
 molecular_functionGO:0034988 Fc-gamma receptor I complex binding ISS
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0048365 Rac GTPase binding ISS
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0051020 GTPase binding ISO


Pathways (from Reactome)
Pathway description
Platelet degranulation
GP1b-IX-V activation signalling
Cell-extracellular matrix interactions
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

Allelic Composition: FlnaDilp2/Flna+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: FlnaDilp2/Flna+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flnatm1.2Caw/Flna+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

Allelic Composition: FlnaDilp2/Flna+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000771 abnormal brain size "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001319 irregularly shaped pupil "shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: FlnaDilp2/Flna+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flnatm1.2Caw/Flna+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Flnatm1.2Caw/Flna+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Flnatm1.2Caw/Flna+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Flnatm1.2Caw/Flna+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: FlnaDilp2/Y
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: FlnaDilp2/Y
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0003649 reduced right ventricle 
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flnatm1.2Caw/Flna+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flnatm1.2Caw/Flna+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: FlnaDilp2/Flna+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

Allelic Composition: FlnaDilp2/Flna+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6

Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0010432 common ventricle "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010620 thick mitral valve 
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Flnatm1.2Caw/Flna+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Flnatm1.1Caw/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Phox2bDilp1/Phox2b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: FlnaDilp2/Y
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ace2tm1Cof/Y
Genetic Background: B6.129S6-Ace2tm1Cof

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Flnatm1.2Caw/Flna+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Flnatm1.2Caw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / reaction / complex
 ENSMUSG00000047953 Gp5 / glycoprotein V platelet / P40197*  / complex / reaction
 ENSMUSG00000050761 Gp1bb / P56400 / glycoprotein Ib, beta polypeptide / P13224* / glycoprotein Ib platelet beta subunit*  / reaction / complex
 ENSMUSG00000031328 Flna / Q8BTM8 / Filamin-A / P21333*  / complex
 ENSMUSG00000030054 Gp9 / O88186 / glycoprotein 9 (platelet) / P14770* / glycoprotein IX platelet*  / reaction / complex
 ENSMUSG00000050675 Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*  / reaction / complex
 ENSMUSG00000006219 Fblim1 / Q71FD7 / Filamin-binding LIM protein 1 / Q8WUP2*  / reaction / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex






 

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