ENSMUSG00000006219


Mus musculus

Features
Gene ID: ENSMUSG00000006219
  
Biological name :Fblim1
  
Synonyms : Fblim1 / Filamin-binding LIM protein 1 / Q71FD7
  
Possible biological names infered from orthology : Q8WUP2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 141576062
Gene end: 141606096
  
Corresponding Affymetrix probe sets: 10517967 (MoGene1.0st)   1418569_at (Mouse Genome 430 2.0 Array)   1449141_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115992
Ensembl peptide - ENSMUSP00000123669
Ensembl peptide - ENSMUSP00000123322
Ensembl peptide - ENSMUSP00000121037
Ensembl peptide - ENSMUSP00000120600
Ensembl peptide - ENSMUSP00000120028
Ensembl peptide - ENSMUSP00000118647
Ensembl peptide - ENSMUSP00000116596
Ensembl peptide - ENSMUSP00000116589
Ensembl peptide - ENSMUSP00000116395
Ensembl peptide - ENSMUSP00000006381
Ensembl peptide - ENSMUSP00000101410
Ensembl peptide - ENSMUSP00000101411
Ensembl peptide - ENSMUSP00000114313
NCBI entrez gene - 74202     See in Manteia.
MGI - MGI:1921452
RefSeq - XM_006539216
RefSeq - NM_001163256
RefSeq - NM_133754
RefSeq - XM_006539213
RefSeq - XM_006539214
RefSeq - XM_006539215
RefSeq Peptide - NP_598515
RefSeq Peptide - NP_001156728
swissprot - A2ADF3
swissprot - Q71FD7
swissprot - A2ADF4
swissprot - A2ADF2
swissprot - A2ADF1
swissprot - A2ADE9
swissprot - A2ADE8
swissprot - A2ADE6
swissprot - A2ADE7
swissprot - A2ADE5
Ensembl - ENSMUSG00000006219
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fblim1ENSDARG00000071558Danio rerio
 FBLIM1ENSGALG00000003636Gallus gallus
 FBLIM1ENSG00000162458Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zyx / zyxin / Q62523 / Q15942*ENSMUSG0000002986035
Trip6 / Q9Z1Y4 / thyroid hormone receptor interactor 6 / Q15654*ENSMUSG0000002334831
Lpp / Q8BFW7 / Lipoma-preferred partner homolog / Q93052* / LIM domain containing preferred translocation partner in lipoma*ENSMUSG0000003330631
Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*ENSMUSG0000002523928
Ajuba / Q91XC0 / LIM domain-containing protein ajuba / Q96IF1* / ajuba LIM protein*ENSMUSG0000002217827
Wtip / Q7TQJ8 / WT1-interacting protein / A6NIX2*ENSMUSG0000003645923
Ablim2 / Q8BL65 / actin-binding LIM protein 2 / Q6H8Q1* / actin binding LIM protein family member 2*ENSMUSG0000002909518
Ablim1 / Q8K4G5 / actin-binding LIM protein 1 / O14639*ENSMUSG0000002508517
Ablim3 / Q69ZX8 / actin binding LIM protein family, member 3 / O94929*ENSMUSG0000003273516
Dmtn / Q9WV69 / Dematin / Q08495* / dematin actin binding protein*ENSMUSG000000220996


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0033623 regulation of integrin activation ISO
 biological_processGO:0098609 cell-cell adhesion ISS
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0001725 stress fiber ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0030054 cell junction ISO
 molecular_functionGO:0031005 filamin binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cell-extracellular matrix interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gjc1tm1.2(Gjd2)Kwi/Gjc1tm1.2(Gjd2)Kwi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031328 Flna / Q8BTM8 / Filamin-A / P21333*  / complex / reaction
 ENSMUSG00000030403 Vasp / P70460 / vasodilator-stimulated phosphoprotein / P50552*  / reaction / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / reaction / complex
 ENSMUSG00000068699 Flnc / Q8VHX6 / Filamin-C / Q14315*  / reaction / complex
 ENSMUSG00000037712 Fermt2 / Q8CIB5 / Fermitin family homolog 2 / Q96AC1* / fermitin family member 2*  / complex / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex






 

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