ENSMUSG00000037712


Mus musculus

Features
Gene ID: ENSMUSG00000037712
  
Biological name :Fermt2
  
Synonyms : Fermitin family homolog 2 / Fermt2 / Q8CIB5
  
Possible biological names infered from orthology : fermitin family member 2 / Q96AC1
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 45458795
Gene end: 45530118
  
Corresponding Affymetrix probe sets: 10419223 (MoGene1.0st)   1434180_at (Mouse Genome 430 2.0 Array)   1434181_at (Mouse Genome 430 2.0 Array)   1459324_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120918
Ensembl peptide - ENSMUSP00000153760
Ensembl peptide - ENSMUSP00000044554
Ensembl peptide - ENSMUSP00000118214
NCBI entrez gene - 218952     See in Manteia.
MGI - MGI:2385001
RefSeq - XM_006518826
RefSeq - XM_006518827
RefSeq - XM_006518828
RefSeq - NM_146054
RefSeq Peptide - NP_666166
swissprot - Q3TLE2
swissprot - A6X940
swissprot - A6X941
swissprot - Q8CIB5
Ensembl - ENSMUSG00000037712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F1Q8X5ENSDARG00000020242Danio rerio
 FERMT2ENSGALG00000012425Gallus gallus
 FERMT2ENSG00000073712Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fermt1 / P59113 / Fermitin family homolog 1 / Q9BQL6* / fermitin family member 1*ENSMUSG0000002735663
Fermt3 / Q8K1B8 / Fermitin family homolog 3 / Q86UX7* / fermitin family member 3*ENSMUSG0000002496551


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0033622 integrin activation IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0048041 focal adhesion assembly IMP
 biological_processGO:0072657 protein localization to membrane IMP
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0031674 I band IEA
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Cell-extracellular matrix interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0000075 absent neurocranium "missing bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Whrnhb/Whrnhb
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Whrnhb/Whrnhb
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Whrnhb/Whrnhb
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002543 brachyphalangia "abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004337 clavicle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004338 small clavicle "reduced size of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004340 short scapula "reduced length of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004610 small vertebrae "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0004626 vertebral compression "appearance of vertebrae that are flattened laterally along the whole length such that they appear pressed together and take up less rostrocaudal space " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008817 hematoma "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fermt2Gt(AM0293)Wtsi/Fermt2Gt(AM0293)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012279 wide sternum "an increase in the width of the long flat bone of the chest that articulates with the clavicle and first seven rib pairs" [MGI:anna]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0013624 decreased femur compact bone thickness "reduced width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith]
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Allelic Composition: Fermt2tm1.1Gxo/Fermt2tm1.1Gxo,Tg(Col2a1-cre)1Bhr/0
Genetic Background: B6.Cg-Fermt2tm1.1Gxo Tg(Col2a1-cre)1Bhr

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0014103 increased chondrocyte apoptosis "increased number of chondrocytes undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006219 Fblim1 / Q71FD7 / Filamin-binding LIM protein 1 / Q8WUP2*  / complex / reaction






 

1 s.

 
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