ENSMUSG00000027356


Mus musculus

Features
Gene ID: ENSMUSG00000027356
  
Biological name :Fermt1
  
Synonyms : Fermitin family homolog 1 / Fermt1 / P59113
  
Possible biological names infered from orthology : fermitin family member 1 / Q9BQL6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F2
Gene start: 132904389
Gene end: 132945906
  
Corresponding Affymetrix probe sets: 10487994 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000047616
NCBI entrez gene - 241639     See in Manteia.
MGI - MGI:2443583
RefSeq - XM_017318210
RefSeq - NM_198029
RefSeq - XM_017318206
RefSeq - XM_017318207
RefSeq - XM_006499507
RefSeq Peptide - NP_932146
swissprot - P59113
Ensembl - ENSMUSG00000027356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fermt1ENSDARG00000052652Danio rerio
 FERMT1ENSGALG00000008827Gallus gallus
 FERMT1ENSG00000101311Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fermt2 / Q8CIB5 / Fermitin family homolog 2 / Q96AC1* / fermitin family member 2*ENSMUSG0000003771263
Fermt3 / Q8K1B8 / Fermitin family homolog 3 / Q86UX7* / fermitin family member 3*ENSMUSG0000002496552


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IMP
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0042308 negative regulation of protein import into nucleus IMP
 biological_processGO:0043616 keratinocyte proliferation IEA
 biological_processGO:0051546 keratinocyte migration IEA
 biological_processGO:0051886 negative regulation of timing of anagen IMP
 biological_processGO:0071711 basement membrane organization IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0090162 establishment of epithelial cell polarity IEA
 biological_processGO:2000647 negative regulation of stem cell proliferation IMP
 biological_processGO:2001203 positive regulation of transforming growth factor-beta secretion IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008055 increased urine osmolality "increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009485 distended ileum "an expansion in the volume of the portion of the small intestine that extends from the jejunum to the colon, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009511 distended stomach "an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0030578 decreased keratinocyte adhesion "decreased ability of a keratinocyte to adhere to another cell or to a non-cellular component of the environment" [MGI:anna]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0030584 skin atrophy "acquired diminution of skin tissue associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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