ENSMUSG00000024965


Mus musculus

Features
Gene ID: ENSMUSG00000024965
  
Biological name :Fermt3
  
Synonyms : Fermitin family homolog 3 / Fermt3 / Q8K1B8
  
Possible biological names infered from orthology : fermitin family member 3 / Q86UX7
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 6998958
Gene end: 7019469
  
Corresponding Affymetrix probe sets: 10465587 (MoGene1.0st)   1433963_a_at (Mouse Genome 430 2.0 Array)   1433964_s_at (Mouse Genome 430 2.0 Array)   1443641_at (Mouse Genome 430 2.0 Array)   1456014_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037858
NCBI entrez gene - 108101     See in Manteia.
MGI - MGI:2147790
RefSeq - XM_006526593
RefSeq - NM_153795
RefSeq Peptide - NP_722490
swissprot - Q3TEE6
swissprot - Q8K1B8
Ensembl - ENSMUSG00000024965
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fermt3bENSDARG00000030938Danio rerio
 im:7154036ENSDARG00000079267Danio rerio
 FERMT3ENSG00000149781Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fermt1 / P59113 / Fermitin family homolog 1 / Q9BQL6* / fermitin family member 1*ENSMUSG0000002735653
Fermt2 / Q8CIB5 / Fermitin family homolog 2 / Q96AC1* / fermitin family member 2*ENSMUSG0000003771252


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway ISO
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0033622 integrin activation IEA
 biological_processGO:0033632 regulation of cell-cell adhesion mediated by integrin ISS
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0070527 platelet aggregation IMP
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cftrtm1Hsc/Cftrtm1Hsc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cftrtm1Hsc/Cftrtm1Hsc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0008816 petechiae "very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0010177 acanthocytosis "presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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