ENSMUSG00000047953


Mus musculus

Features
Gene ID: ENSMUSG00000047953
  
Biological name :Gp5
  
Synonyms : glycoprotein V platelet / Gp5
  
Possible biological names infered from orthology : P40197
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B2
Gene start: 30307686
Gene end: 30310779
  
Corresponding Affymetrix probe sets: 10438907 (MoGene1.0st)   1422817_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051895
NCBI entrez gene - 14729     See in Manteia.
MGI - MGI:1096363
RefSeq - NM_008148
RefSeq Peptide - NP_032174
swissprot - Q9QZU3
Ensembl - ENSMUSG00000047953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-117l17.7ENSDARG00000100217Danio rerio
 GP5ENSGALG00000045125Gallus gallus
 GP5ENSG00000178732Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc15 / Q80X72 / Leucine-rich repeat-containing protein 15 / Q8TF66* / leucine rich repeat containing 15*ENSMUSG0000005231630
Cpn2 / Q9DBB9 / Carboxypeptidase N subunit 2 / P22792*ENSMUSG0000002317629
Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*ENSMUSG0000004607023
Chadl / E9Q7T7 / Chondroadherin-like protein / Q6NUI6* / chondroadherin like*ENSMUSG0000006376523
Tril / Q9DBY4 / TLR4 interactor with leucine rich repeats / Q7L0X0*ENSMUSG0000004349623
Lrrtm2 / Q8BGA3 / Leucine-rich repeat transmembrane neuronal protein 2 / O43300* / leucine rich repeat transmembrane neuronal 2*ENSMUSG0000007186220
Lrrtm4 / Q80XG9 / Mus musculus leucine rich repeat transmembrane neuronal 4 (Lrrtm4), transcript variant 4, mRNA. / Q86VH4* / leucine rich repeat transmembrane neuronal 4*ENSMUSG0000005258120
Nyx / P83503 / Nyctalopin / Q9GZU5*ENSMUSG0000005122820
Lrrtm3 / Q8BZ81 / Leucine-rich repeat transmembrane neuronal protein 3 / Q86VH5* / leucine rich repeat transmembrane neuronal 3*ENSMUSG0000004284619
Lrrtm1 / Q8K377 / Leucine-rich repeat transmembrane neuronal protein 1 / Q86UE6* / leucine rich repeat transmembrane neuronal 1*ENSMUSG0000006078019
Chad / O55226 / Chondroadherin / O15335*ENSMUSG0000003908414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021492 F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*  / reaction
 ENSMUSG00000031328 Flna / Q8BTM8 / Filamin-A / P21333*  / complex / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / complex / reaction
 ENSMUSG00000030054 Gp9 / O88186 / glycoprotein 9 (platelet) / P14770* / glycoprotein IX platelet*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000031645 F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*  / reaction / complex
 ENSMUSG00000050761 Gp1bb / P56400 / glycoprotein Ib, beta polypeptide / P13224* / glycoprotein Ib platelet beta subunit*  / complex
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / reaction / complex
 ENSMUSG00000050675 Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*  / complex
 ENSMUSG00000031138 F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*  / reaction






 

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