ENSMUSG00000046070


Mus musculus

Features
Gene ID: ENSMUSG00000046070
  
Biological name :Igfals
  
Synonyms : Igfals / insulin-like growth factor binding protein, acid labile subunit
  
Possible biological names infered from orthology : P35858
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 24878770
Gene end: 24882008
  
Corresponding Affymetrix probe sets: 10442625 (MoGene1.0st)   1422826_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060169
NCBI entrez gene - 16005     See in Manteia.
MGI - MGI:107973
RefSeq - NM_008340
RefSeq Peptide - NP_032366
swissprot - A0A0R4J0S2
Ensembl - ENSMUSG00000046070
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfalsENSDARG00000037836Danio rerio
 IGFALSENSGALG00000002325Gallus gallus
 IGFALSENSG00000099769Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chadl / E9Q7T7 / Chondroadherin-like protein / Q6NUI6* / chondroadherin like*ENSMUSG0000006376531
Cpn2 / Q9DBB9 / Carboxypeptidase N subunit 2 / P22792*ENSMUSG0000002317623
Lrrc15 / Q80X72 / Leucine-rich repeat-containing protein 15 / Q8TF66* / leucine rich repeat containing 15*ENSMUSG0000005231623
Nyx / P83503 / Nyctalopin / Q9GZU5*ENSMUSG0000005122822
Gp5 / glycoprotein V platelet / P40197*ENSMUSG0000004795322
Tril / Q9DBY4 / TLR4 interactor with leucine rich repeats / Q7L0X0*ENSMUSG0000004349620
Lrrtm2 / Q8BGA3 / Leucine-rich repeat transmembrane neuronal protein 2 / O43300* / leucine rich repeat transmembrane neuronal 2*ENSMUSG0000007186217
Lrrtm4 / Q80XG9 / Mus musculus leucine rich repeat transmembrane neuronal 4 (Lrrtm4), transcript variant 4, mRNA. / Q86VH4* / leucine rich repeat transmembrane neuronal 4*ENSMUSG0000005258117
Lrrtm3 / Q8BZ81 / Leucine-rich repeat transmembrane neuronal protein 3 / Q86VH5* / leucine rich repeat transmembrane neuronal 3*ENSMUSG0000004284616
Lrrtm1 / Q8K377 / Leucine-rich repeat transmembrane neuronal protein 1 / Q86UE6* / leucine rich repeat transmembrane neuronal 1*ENSMUSG0000006078016
Chad / O55226 / Chondroadherin / O15335*ENSMUSG0000003908415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0042567 insulin-like growth factor ternary complex IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Igfalstm1Yrb/Igfalstm1Yrb,Tg(Alb1-cre)1Dlr/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040314 Ctsg / P28293 / cathepsin G / P08311*  / reaction
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000031740 Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*  / reaction
 ENSMUSG00000026185 Igfbp5 / Q07079 / Insulin-like growth factor-binding protein 5 / P24593*  / complex / reaction
 ENSMUSG00000020427 Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*  / complex / reaction
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / complex / reaction
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / reaction / complex
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction
 ENSMUSG00000028370 Pappa / Q8R4K8 / Pappalysin-1 / Q13219*  / reaction
 ENSMUSG00000073530 Pappa2 / pappalysin 2 / Q9BXP8*  / reaction






 

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