ENSMUSG00000060780


Mus musculus

Features
Gene ID: ENSMUSG00000060780
  
Biological name :Lrrtm1
  
Synonyms : Leucine-rich repeat transmembrane neuronal protein 1 / Lrrtm1 / Q8K377
  
Possible biological names infered from orthology : leucine rich repeat transmembrane neuronal 1 / Q86UE6
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 77242689
Gene end: 77257791
  
Corresponding Affymetrix probe sets: 10539169 (MoGene1.0st)   1437746_at (Mouse Genome 430 2.0 Array)   1452624_at (Mouse Genome 430 2.0 Array)   1455883_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124948
Ensembl peptide - ENSMUSP00000125207
Ensembl peptide - ENSMUSP00000020400
Ensembl peptide - ENSMUSP00000124373
NCBI entrez gene - 74342     See in Manteia.
MGI - MGI:2389173
RefSeq - NM_028880
RefSeq - XM_006506712
RefSeq Peptide - NP_083156
swissprot - E0CX41
swissprot - Q8K377
Ensembl - ENSMUSG00000060780
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrtm1ENSDARG00000052713Danio rerio
 LRRTM1ENSGALG00000015967Gallus gallus
 LRRTM1ENSG00000162951Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrtm2 / Q8BGA3 / Leucine-rich repeat transmembrane neuronal protein 2 / O43300* / leucine rich repeat transmembrane neuronal 2*ENSMUSG0000007186247
Lrrtm4 / Q80XG9 / Mus musculus leucine rich repeat transmembrane neuronal 4 (Lrrtm4), transcript variant 4, mRNA. / Q86VH4* / leucine rich repeat transmembrane neuronal 4*ENSMUSG0000005258145
Lrrtm3 / Q8BZ81 / Leucine-rich repeat transmembrane neuronal protein 3 / Q86VH5* / leucine rich repeat transmembrane neuronal 3*ENSMUSG0000004284645
Tril / Q9DBY4 / TLR4 interactor with leucine rich repeats / Q7L0X0*ENSMUSG0000004349622
Chadl / E9Q7T7 / Chondroadherin-like protein / Q6NUI6* / chondroadherin like*ENSMUSG0000006376520
Gp5 / glycoprotein V platelet / P40197*ENSMUSG0000004795320
Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*ENSMUSG0000004607019
Lrrc15 / Q80X72 / Leucine-rich repeat-containing protein 15 / Q8TF66* / leucine rich repeat containing 15*ENSMUSG0000005231617
Nyx / P83503 / Nyctalopin / Q9GZU5*ENSMUSG0000005122817
Cpn2 / Q9DBB9 / Carboxypeptidase N subunit 2 / P22792*ENSMUSG0000002317616
Chad / O55226 / Chondroadherin / O15335*ENSMUSG000000390849


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002091 negative regulation of receptor internalization IGI
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0035418 protein localization to synapse IMP
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050808 synapse organization ISO
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0060291 long-term synaptic potentiation IGI
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0030426 growth cone ISO
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060076 excitatory synapse ISO
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0009455 enhanced cued conditioning behavior "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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