ENSMUSG00000052581


Mus musculus

Features
Gene ID: ENSMUSG00000052581
  
Biological name :Lrrtm4
  
Synonyms : Lrrtm4 / Mus musculus leucine rich repeat transmembrane neuronal 4 (Lrrtm4), transcript variant 4, mRNA. / Q80XG9
  
Possible biological names infered from orthology : leucine rich repeat transmembrane neuronal 4 / Q86VH4
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 80018877
Gene end: 80810143
  
Corresponding Affymetrix probe sets: 10539211 (MoGene1.0st)   1437214_at (Mouse Genome 430 2.0 Array)   1455937_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117263
Ensembl peptide - ENSMUSP00000115016
Ensembl peptide - ENSMUSP00000117445
Ensembl peptide - ENSMUSP00000121621
Ensembl peptide - ENSMUSP00000121124
Ensembl peptide - ENSMUSP00000074232
Ensembl peptide - ENSMUSP00000114425
Ensembl peptide - ENSMUSP00000114465
NCBI entrez gene - 243499     See in Manteia.
MGI - MGI:2389180
RefSeq - XM_011241336
RefSeq - NM_001134743
RefSeq - NM_001282102
RefSeq - NM_001347261
RefSeq - NM_178731
RefSeq - XM_006506085
RefSeq - XM_006506086
RefSeq - XM_006506087
RefSeq - XM_006506088
RefSeq - XM_006506089
RefSeq Peptide - NP_001269031
RefSeq Peptide - NP_001334190
RefSeq Peptide - NP_848846
RefSeq Peptide - NP_001128215
swissprot - E9Q8Y9
swissprot - Q80XG9
swissprot - D3YVI4
swissprot - D3YVG2
swissprot - A0A0R4J1T4
Ensembl - ENSMUSG00000052581
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01102147.1ENSDARG00000106522Danio rerio
 lrrtm4l1ENSDARG00000080015Danio rerio
 lrrtm4l2ENSDARG00000099386Danio rerio
 si:dkey-28o19.1ENSDARG00000078839Danio rerio
 LRRTM4ENSGALG00000000476Gallus gallus
 LRRTM4ENSG00000176204Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrtm3 / Q8BZ81 / Leucine-rich repeat transmembrane neuronal protein 3 / Q86VH5* / leucine rich repeat transmembrane neuronal 3*ENSMUSG0000004284658
Lrrtm1 / Q8K377 / Leucine-rich repeat transmembrane neuronal protein 1 / Q86UE6* / leucine rich repeat transmembrane neuronal 1*ENSMUSG0000006078040
Lrrtm2 / Q8BGA3 / Leucine-rich repeat transmembrane neuronal protein 2 / O43300* / leucine rich repeat transmembrane neuronal 2*ENSMUSG0000007186237
Tril / Q9DBY4 / TLR4 interactor with leucine rich repeats / Q7L0X0*ENSMUSG0000004349621
Lrrc15 / Q80X72 / Leucine-rich repeat-containing protein 15 / Q8TF66* / leucine rich repeat containing 15*ENSMUSG0000005231619
Gp5 / glycoprotein V platelet / P40197*ENSMUSG0000004795319
Chadl / E9Q7T7 / Chondroadherin-like protein / Q6NUI6* / chondroadherin like*ENSMUSG0000006376518
Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*ENSMUSG0000004607017
Cpn2 / Q9DBB9 / Carboxypeptidase N subunit 2 / P22792*ENSMUSG0000002317617
Nyx / P83503 / Nyctalopin / Q9GZU5*ENSMUSG0000005122816
Chad / O55226 / Chondroadherin / O15335*ENSMUSG000000390848


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050808 synapse organization ISO
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0072578 neurotransmitter-gated ion channel clustering IDA
 biological_processGO:0097113 AMPA glutamate receptor clustering IMP
 biological_processGO:1901629 regulation of presynaptic membrane organization IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IDA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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