ENSMUSG00000039084


Mus musculus

Features
Gene ID: ENSMUSG00000039084
  
Biological name :Chad
  
Synonyms : Chad / Chondroadherin / O55226
  
Possible biological names infered from orthology : O15335
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 94565047
Gene end: 94569127
  
Corresponding Affymetrix probe sets: 10380398 (MoGene1.0st)   1420569_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047844
NCBI entrez gene - 12643     See in Manteia.
MGI - MGI:1096866
RefSeq - NM_007689
RefSeq Peptide - NP_031715
swissprot - O55226
swissprot - Q3TYW1
Ensembl - ENSMUSG00000039084
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chadENSDARG00000045071Danio rerio
 CHADENSGALG00000019761Gallus gallus
 CHADENSG00000136457Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chadl / E9Q7T7 / Chondroadherin-like protein / Q6NUI6* / chondroadherin like*ENSMUSG0000006376539
Lrrc15 / Q80X72 / Leucine-rich repeat-containing protein 15 / Q8TF66* / leucine rich repeat containing 15*ENSMUSG0000005231625
Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*ENSMUSG0000004607025
Cpn2 / Q9DBB9 / Carboxypeptidase N subunit 2 / P22792*ENSMUSG0000002317623
Gp5 / glycoprotein V platelet / P40197*ENSMUSG0000004795323
Tril / Q9DBY4 / TLR4 interactor with leucine rich repeats / Q7L0X0*ENSMUSG0000004349619
Nyx / P83503 / Nyctalopin / Q9GZU5*ENSMUSG0000005122819
Lrrtm2 / Q8BGA3 / Leucine-rich repeat transmembrane neuronal protein 2 / O43300* / leucine rich repeat transmembrane neuronal 2*ENSMUSG0000007186214
Lrrtm4 / Q80XG9 / Mus musculus leucine rich repeat transmembrane neuronal 4 (Lrrtm4), transcript variant 4, mRNA. / Q86VH4* / leucine rich repeat transmembrane neuronal 4*ENSMUSG0000005258113
Lrrtm3 / Q8BZ81 / Leucine-rich repeat transmembrane neuronal protein 3 / Q86VH5* / leucine rich repeat transmembrane neuronal 3*ENSMUSG0000004284613
Lrrtm1 / Q8K377 / Leucine-rich repeat transmembrane neuronal protein 1 / Q86UE6* / leucine rich repeat transmembrane neuronal 1*ENSMUSG0000006078013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0060348 bone development IMP
 biological_processGO:1900155 negative regulation of bone trabecula formation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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