ENSMUSG00000073530


Mus musculus

Features
Gene ID: ENSMUSG00000073530
  
Biological name :Pappa2
  
Synonyms : Pappa2 / pappalysin 2
  
Possible biological names infered from orthology : Q9BXP8
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H1
Gene start: 158711727
Gene end: 158980490
  
Corresponding Affymetrix probe sets: 10359266 (MoGene1.0st)   10359280 (MoGene1.0st)   10359282 (MoGene1.0st)   1444451_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124316
Ensembl peptide - ENSMUSP00000124022
NCBI entrez gene - 23850     See in Manteia.
MGI - MGI:3051647
RefSeq - XM_006496823
RefSeq - XM_011238806
RefSeq - NM_001085376
RefSeq - XM_006496824
RefSeq Peptide - NP_001078845
swissprot - F6TFC9
swissprot - E9PZ87
Ensembl - ENSMUSG00000073530
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pappa2ENSDARG00000076020Danio rerio
 ENSGALG00000040432Gallus gallus
 PAPPA2ENSG00000116183Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pappa / Q8R4K8 / Pappalysin-1 / Q13219*ENSMUSG0000002837041


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000800  Notch domain
 IPR006558  LamG-like jellyroll fold
 IPR008754  Peptidase M43, pregnancy-associated plasma-A
 IPR011936  Myxococcus cysteine-rich repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR026918  Pappalysin-2
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0009651 response to salt stress IEA
 biological_processGO:0060349 bone morphogenesis IMP
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008237 metallopeptidase activity ISO
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pappa2M1Btlr/Pappa2+
Genetic Background: C57BL/6J-Pappa2M1Btlr

Allelic Composition: Pappa2M1Btlr/Pappa2M1Btlr
Genetic Background: C57BL/6J-Pappa2M1Btlr

Allelic Composition: Pappa2M2Btlr/Pappa2M2Btlr
Genetic Background: C57BL/6J-Pappa2M2Btlr

Allelic Composition: Pappa2M2Btlr/Pappa2+
Genetic Background: C57BL/6J-Pappa2M2Btlr

Allelic Composition: Pappa2m3Btlr/Pappa2m3Btlr
Genetic Background: C57BL/6J-Pappa2m3Btlr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0010114 abnormal coccyx morphology "any structural anomaly of the rostral-most segment of the vertebral column that is formed by the fusion of three to five coccygeal vertebrae in adult humans and tailless primates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
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Allelic Composition: Pappa2tm1.1Jkcs/Pappa2tm1.1Jkcs
Genetic Background: involves: BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026185 Igfbp5 / Q07079 / Insulin-like growth factor-binding protein 5 / P24593*  / reaction
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / reaction
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / reaction
 ENSMUSG00000017493 Igfbp4 / P47879 / Insulin-like growth factor-binding protein 4 / P22692*  / reaction
 ENSMUSG00000046070 Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction






 

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