ENSDARG00000076020


Danio rerio

Features
Gene ID: ENSDARG00000076020
  
Biological name :pappa2
  
Synonyms : pappa2 / pappalysin 2
  
Possible biological names infered from orthology : Q9BXP8
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 34986201
Gene end: 35103069
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000104154
NCBI entrez gene - 567038     See in Manteia.
RefSeq - XM_009298646
RefSeq - XM_690325
swissprot - E9QCK7
ZFIN ID - ZDB-GENE-070912-525
Ensembl - ENSDARG00000076020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040432Gallus gallus
 PAPPA2ENSG00000116183Homo sapiens
 Pappa2ENSMUSG00000073530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pappaa / pregnancy-associated plasma protein A, pappalysin 1a / PAPPA* / Q8R4K8* / Q13219* / pappalysin 1*ENSDARG0000010109040
pappab / pregnancy-associated plasma protein A, pappalysin 1b / PAPPA* / Q8R4K8* / Q13219* / pappalysin 1*ENSDARG0000005985839


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000800  Notch domain
 IPR006558  LamG-like jellyroll fold
 IPR008754  Peptidase M43, pregnancy-associated plasma-A
 IPR011936  Myxococcus cysteine-rich repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR026918  Pappalysin-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0051216 cartilage development IMP
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037836 igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction
 ENSDARG00000025348 igfbp5b / insulin-like growth factor binding protein 5b / Q07079* / IGFBP5* / P24593* / insulin like growth factor binding protein 5*  / reaction
 ENSDARG00000039264 igfbp5a / insulin-like growth factor binding protein 5a / IGFBP5* / P24593* / insulin like growth factor binding protein 5*  / reaction
 ENSDARG00000094132 igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *  / reaction
 ENSDARG00000033307 igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction






 

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