ENSDARG00000033307


Danio rerio

Features
Gene ID: ENSDARG00000033307
  
Biological name :igf2b
  
Synonyms : igf2b / insulin-like growth factor 2b
  
Possible biological names infered from orthology : IGF2 / insulin like growth factor 2 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344 / P09535
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 24039364
Gene end: 24046870
  
Corresponding Affymetrix probe sets: Dr.9288.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000047568
NCBI entrez gene - 324215     See in Manteia.
RefSeq - NM_001001815
RefSeq Peptide - NP_001001815
swissprot - Q8JIE4
ZFIN ID - ZDB-GENE-030131-2935
Ensembl - ENSDARG00000033307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGF2ENSGALG00000035282Gallus gallus
 IGF2ENSG00000167244Homo sapiens
 Igf2ENSMUSG00000048583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
igf2a / insulin-like growth factor 2a / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*ENSDARG0000001864346
igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *ENSDARG0000009413229
igf3 / insulin-like growth factor 3ENSDARG0000005805826


Protein motifs (from Interpro)
Interpro ID Name
 IPR013576  Insulin-like growth factor II E-peptide, C-terminal
 IPR016179  Insulin-like
 IPR022334  Insulin-like growth factor II
 IPR022350  Insulin-like growth factor
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0048793 pronephros development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IDA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood decreased fluid flow , abnormal
Show

 ZFA:0000008 brain brain structure , abnormal
Show

 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm distended , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000109 forebrain forebrain morphology , abnormal
Show

 ZFA:0000114 heart heart increased size , abnormal
Show

 ZFA:0000131 neural keel neural keel apoptotic , abnormal
Show

 ZFA:0000135 notochord notochord undulate , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct medial side fused with pronephric duct medial side, abnormal
Show

 ZFA:0000155 somite somite morphology , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism wholly ventralized , abnormal
whole organism curved ventral , abnormal
whole organism edematous , abnormal
Show

 ZFA:0001115 trunk trunk has fewer parts of type somite , abnormal
Show

 ZFA:0005024 trunk vasculature trunk vasculature increased accumulation blood , abnormal
Show

 ZFA:0005037 post-vent vasculature post-vent vasculature increased accumulation blood , abnormal
Show

 ZFA:0005249 vasculature vasculature increased accumulation blood , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000027423 igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*  / reaction / complex
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / complex / reaction
 ENSDARG00000031422 igfbp2b / insulin-like growth factor binding protein 2b / P47877* / IGFBP2* / P18065* / insulin like growth factor binding protein 2*  / complex / reaction
 ENSDARG00000034434 igf1rb / insulin-like growth factor 1b receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*  / reaction / complex
 ENSDARG00000023111 plg / plasminogen / LPA* / P08519* / P20918* / P00747* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSDARG00000038666 igfbp1b / insulin-like growth factor binding protein 1b / P47876* / IGFBP1* / P08833* / insulin like growth factor binding protein 1*  / reaction / complex
 ENSDARG00000039264 igfbp5a / insulin-like growth factor binding protein 5a / IGFBP5* / P24593* / insulin like growth factor binding protein 5*  / complex / reaction
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSDARG00000052470 Q9PTH3 / igfbp2a / insulin-like growth factor binding protein 2a / IGFBP2* / P18065* / insulin like growth factor binding protein 2*  / reaction / complex
 ENSDARG00000025348 igfbp5b / insulin-like growth factor binding protein 5b / Q07079* / IGFBP5* / P24593* / insulin like growth factor binding protein 5*  / reaction / complex
 ENSDARG00000037836 igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction / complex
 ENSDARG00000076020 pappa2 / pappalysin 2 / Q9BXP8*  / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction / complex
 ENSDARG00000070941 igfbp6a / insulin-like growth factor binding protein 6a / IGFBP6* / P24592* / insulin like growth factor binding protein 6*  / complex / reaction
 ENSDARG00000090833 igfbp6b / insulin-like growth factor binding protein 6b / IGFBP6* / P24592* / insulin like growth factor binding protein 6*  / reaction / complex
 ENSDARG00000099144 igfbp3 / insulin-like growth factor binding protein 3 / P17936* / P47878*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr